Jarosz P J, Parrott E L
J Pharm Sci. 1983 May;72(5):530-5. doi: 10.1002/jps.2600720513.
The granule strength (crushing load) of lactose granulated with 1-9% povidone was measured initially and at intervals during a 1-year period. The granule strengths of dibasic calcium phosphate dihydrate granulated with various concentrations of starch and povidone were measured. The axial and radial tensile strengths of tablets compressed from these granules were determined and related to concentration of binder and granule strength. The effect of compressional force on the integrity of granules in a tablet matrix is shown in scanning electron photomicrographs of the fractured tablets which had undergone a diametral compression test. It appears that the compressional force and the concentration of binder contribute more than granule strength to tablet tensile strength.
首先测量了用1%-9%聚维酮制粒的乳糖颗粒强度（抗压负荷），并在1年期间内定期测量。还测量了用不同浓度淀粉和聚维酮制粒的二水磷酸氢钙的颗粒强度。测定了由这些颗粒压制的片剂的轴向和径向抗张强度，并将其与粘合剂浓度和颗粒强度相关联。在经过径向压缩试验的破碎片剂的扫描电子显微照片中，显示了压缩力对片剂基质中颗粒完整性的影响。似乎压缩力和粘合剂浓度对片剂抗张强度的贡献比颗粒强度更大。
