Huang Fengjie, Wu Wutong
School of Life Science and Technology, China Pharmaceutical University, Nanjing 210009, China.
J Pharm Pharmacol. 2005 Dec;57(12):1575-80. doi: 10.1211/jpp.57.12.0007.
We have evaluated the antidiabetic effect of S-8300 (a peptide extracted from shark liver (Squalus mitsukurii)) in streptozocin (streptozotocin)-diabetic mice. Diabetes was induced by a single intravenous injection of streptozocin (150 mg kg(-1)). The effects of S-8300 (3 or 10 mg kg(-1)) on diabetic mice were investigated by observing the changes in the levels of fasting plasma glucose, glycosylated haemoglobin, hepatic glycogen, triglycerides, cholesterol, free fatty acid, superoxide dismutase, and malondialdehyde. Body weight, kidney weight and the degree of injured beta-cells in pancreatic islets were recorded also. Diabetic mice treated with S-8300 showed a significant decrease in the levels of fasting plasma glucose, glycosylated haemoglobin, triglycerides, cholesterol, free fatty acid in plasma and malondialdehyde in tissues. The animals showed a significant increase in the content of hepatic glycogen and the activity of superoxide dismutase. Treatment with S-8300 attenuated the degree of injured beta-cells in the pancreatic islets. The effect of S-8300 was similar to that of glibenclamide (5 mg kg(-1)).
我们评估了S - 8300（一种从鲨肝（姥鲨）中提取的肽）对链脲佐菌素诱导的糖尿病小鼠的抗糖尿病作用。通过单次静脉注射链脲佐菌素（150 mg kg⁻¹）诱导糖尿病。通过观察空腹血糖、糖化血红蛋白、肝糖原、甘油三酯、胆固醇、游离脂肪酸、超氧化物歧化酶和丙二醛水平的变化，研究了S - 8300（3或10 mg kg⁻¹）对糖尿病小鼠的影响。还记录了体重、肾脏重量以及胰岛中β细胞的损伤程度。用S - 8300治疗的糖尿病小鼠空腹血糖、糖化血红蛋白、血浆甘油三酯、胆固醇、血浆游离脂肪酸和组织中丙二醛水平显著降低。动物肝糖原含量和超氧化物歧化酶活性显著增加。S - 8300治疗减轻了胰岛中β细胞的损伤程度。S - 8300的作用与格列本脲（5 mg kg⁻¹）相似。
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