Yunnan Institute of Food Safety, Kunming University of Science and Technology, No. 727 South Jingming Road, Kunming 650500, China.
Nutrients. 2017 Jul 26;9(8):801. doi: 10.3390/nu9080801.
Recent studies have shown that rambutan peel phenolic (RPP) extract demonstrate high antioxidant and antiglycation activities in vitro and in vivo. This study further evaluated the anti-diabetic activity of RPP in a mouse model of Type II diabetes induced by streptozotocin combined with high-fat diet. Results showed that RPP increased the body weight and reduced the fasting blood glucose level of the diabetic mice. RPP significantly reduced the serum levels of total cholesterol, triglyceride, creatinine, and glycated serum protein in diabetic mice in a dose-dependent manner. Glycogen content in mice liver was recovered by RPP, which further increased the activity of superoxide dismutase and glutathione peroxidase and reduced lipid peroxidation in diabetic mice. Histological analysis showed that RPP effectively protected the tissue structure of the liver, kidney, and pancreas. In addition, RPP decreased the mesangial index and inhibited the expression of TGF-β in the kidney of diabetic mice.
最近的研究表明，红毛丹果皮酚（RPP）提取物在体外和体内均表现出较高的抗氧化和抗糖化活性。本研究进一步评估了 RPP 在链脲佐菌素联合高脂肪饮食诱导的 II 型糖尿病小鼠模型中的抗糖尿病活性。结果表明，RPP 增加了糖尿病小鼠的体重，降低了其空腹血糖水平。RPP 可显著降低糖尿病小鼠血清总胆固醇、甘油三酯、肌酐和糖化血清蛋白水平，呈剂量依赖性。RPP 可恢复小鼠肝糖原含量，进一步提高超氧化物歧化酶和谷胱甘肽过氧化物酶的活性，减少糖尿病小鼠的脂质过氧化。组织学分析表明，RPP 可有效保护肝、肾和胰腺的组织结构。此外，RPP 可降低糖尿病小鼠肾脏的系膜指数，并抑制 TGF-β的表达。
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