Gastinger Matthew J, Bordt Andrea S, Bernal Maria P, Marshak David W
Department of Neurobiology and Anatomy, University of Texas Medical School at Houston, Houston, Texas 77225, USA.
Curr Eye Res. 2005 Dec;30(12):1089-95. doi: 10.1080/02713680500371532.
To describe serotonergic retinopetal axons in monkeys.
Whole macaque and baboon retinas, fixed in 4% paraformaldehyde, were labeled with antisera raised against serotonin (5-HT).
Several large-diameter 5-HT-immunoreactive (IR) axons emerged from the optic disk. Most axons ran to the peripheral retina, where they branched extensively. Most terminated in the ganglion cell layer, but a few 5-HT-IR axons terminated in distal inner plexiform or within inner nuclear layer. Some axons branched extensively near the fovea, and a dense plexus of 5-HT-IR axons was also found around the optic disk. Varicose 5-HT-IR axons were also associated with blood vessels, especially in the central retina.
Immunoreactive serotonin is present in a distinct population of retinopetal axons in the monkey retina. Receptors for serotonin are present in the primate retinas, and based on physiological studies in other mammals, these retinopetal axons are expected to modulate neuronal activity and regulate blood flow.
描述猴子体内的血清素能视网膜向心性轴突。
将固定于4%多聚甲醛中的猕猴和狒狒的整个视网膜，用针对血清素（5-羟色胺）的抗血清进行标记。
几条大直径的5-羟色胺免疫反应性（IR）轴突从视盘发出。大多数轴突伸向周边视网膜，在那里它们广泛分支。大多数终止于神经节细胞层，但少数5-羟色胺免疫反应性轴突终止于远端内网状层或内核层内。一些轴突在中央凹附近广泛分支，并且在视盘周围也发现了密集的5-羟色胺免疫反应性轴突丛。有曲张的5-羟色胺免疫反应性轴突也与血管相关，尤其是在视网膜中央。
免疫反应性血清素存在于猴子视网膜中一个独特的视网膜向心性轴突群体中。血清素受体存在于灵长类动物视网膜中，并且基于对其他哺乳动物的生理学研究，这些视网膜向心性轴突有望调节神经元活动并调节血流。
