Tani Edneia, Seregard Stefan, Rupp George, Söderlund Veli, Skoog Lambert
Department of Pathology and Cytology, Karolinska University Hospital, Solna, Stockholm, Sweden.
Diagn Cytopathol. 2006 Jan;34(1):1-5. doi: 10.1002/dc.20375.
A series of 85 fine-needle aspiration (FNA) biopsies from orbital space occupying lesions of 82 patients are reviewed. A total of 32 benign lesions and 49 malignant lesions were conclusively diagnosed. In two cases the aspirates were insufficient for diagnosis. Of two cases, which were cytologically suspicious for lymphoma, a repeat FNA resulted in a conclusive diagnosis of lymphoma in one case, while the second case proved to be a pseudotumor on an open biopsy material. Of the 32 benign lesions seven were fibrosis, six pseudotumors, four epidermal cysts, four meningiomas, and three pleomorphic adenomas. The remaining cases included two hematomas, one granuloma, three inflammations, and one malformation. In 43 of 49 malignant tumors cytomorphology was corroborated with immunocytochemistry. Thirty five of these were low- or high-grade lymphomas, nine metastases, two sarcomas, two plasmacytomas, and one chloroma. All lymphomas were of B phenotype with monoclonal light chain expression. The rate of cell proliferation as measured by Ki-67 immunostaining varied between 4-25% and 30-80% for low- and high-grade lymphomas, respectively. These results confirm previous reports on the usefulness of FNA biopsy in diagnosing orbital masses and emphasize the value of immunocytochemistry in tumor characterization.
回顾了82例患者眼眶占位性病变的85例细针穿刺（FNA）活检。最终确诊32例良性病变和49例恶性病变。2例穿刺样本不足以诊断。在2例细胞学上怀疑为淋巴瘤的病例中，1例重复FNA后确诊为淋巴瘤，而另一例在开放活检材料上被证明是假瘤。32例良性病变中，7例为纤维化，6例为假瘤，4例为表皮样囊肿，4例为脑膜瘤，3例为多形性腺瘤。其余病例包括2例血肿、1例肉芽肿、3例炎症和1例畸形。49例恶性肿瘤中有43例细胞形态学与免疫细胞化学结果相符。其中35例为低级别或高级别淋巴瘤，9例为转移瘤，2例为肉瘤，2例为浆细胞瘤，1例为绿色瘤。所有淋巴瘤均为B表型，具有单克隆轻链表达。通过Ki-67免疫染色测量的细胞增殖率在低级别和高级别淋巴瘤中分别为4%-25%和30%-80%。这些结果证实了先前关于FNA活检在诊断眼眶肿块中的有用性的报道，并强调了免疫细胞化学在肿瘤特征化中的价值。
