Vaden Shelly L, Levine Jay F, Lees George E, Groman Reid P, Grauer Gregory F, Forrester S Dru
Department of Clinical Sciences, College of Veterinary Medicine, North Carolina State University, 4700 Hillsborough Street, Raleigh, NC 27606, USA.
J Vet Intern Med. 2005 Nov-Dec;19(6):794-801. doi: 10.1892/0891-6640(2005)19[794:rbarso]2.0.co;2.
Renal biopsy often is required to establish a definitive diagnosis in dogs and cats with renal disease. In this retrospective study, we determined the complications of renal biopsy as well as factors that may be associated with development of complications and procurement of adequate renal biopsy specimens in 283 dogs and 65 cats. Data extracted from medical records at 4 institutions were evaluated using logistic regression. Proteinuria was the most common indication for renal biopsy in dogs. Complications were reported in 13.4 and 18.5% of dogs and cats, respectively. The most common complication was severe hemorrhage; hydronephrosis and death were uncommon. Dogs that developed complications after renal biopsy were more likely to have been 4 to < 7 years of age and > 9 years, to weigh < or = 5 kg, and to have serum creatinine concentrations > 5 mg/dL. The majority of biopsies from both dogs (87.6%) and cats (86.2%) were considered to be of satisfactory quality. Biopsies from dogs were more likely to be of high quality if they were obtained when the patient was under general anesthesia and more likely to contain only renal cortex if they were obtained by surgery. We concluded that renal biopsy is a relatively safe procedure, with a low frequency of severe complications. Hospital practices and patient variables have the potential to impact both the quality of the specimen obtained and the rate of complications.
对于患有肾脏疾病的犬猫，通常需要进行肾活检以明确诊断。在这项回顾性研究中，我们确定了283只犬和65只猫肾活检的并发症，以及可能与并发症发生和获取足够肾活检标本相关的因素。从4家机构的病历中提取的数据采用逻辑回归进行评估。蛋白尿是犬肾活检最常见的指征。犬和猫的并发症报告发生率分别为13.4%和18.5%。最常见的并发症是严重出血；肾积水和死亡并不常见。肾活检后出现并发症的犬更可能年龄在4至<7岁和>9岁之间，体重≤5 kg，血清肌酐浓度>5 mg/dL。犬（87.6%）和猫（86.2%）的大多数活检标本质量被认为是令人满意的。如果在全身麻醉下获取，犬的活检标本更可能质量高；如果通过手术获取，则更可能仅包含肾皮质。我们得出结论，肾活检是一种相对安全的操作，严重并发症发生率低。医院操作和患者变量有可能影响所获取标本的质量和并发症发生率。
