Launo C, De Grandi R, Augeri C, Palermo S, Riello R, Germi M R, Focacci V, Spirandelli P, Riverso P
Istituto di Anestesiologia e Rianimazione, Università degli Studi di Genova.
Minerva Anestesiol. 1992 May;58(5):245-51.
The score scale of anxiety (STAI, Y, 1-2) and haematic levels of DBI (diazepam binding inhibitor) were used in 48 surgical patients for clinical evaluation of preoperative anxiety, before and after drugs for preoperative medication. After randomization, were clinically and statistically compared 6 groups according to premedicant drugs (diazepam 0.3 mg/kg; flunitrazepam 0.03 mg/kg; saline; prometazine 0.7 mg/kg); before and after preoperative medication were evaluated the anxiety relief with the score scale, haematic levels of DBI and haemodynamics (systolic and diastolic AP and HR). The results show that DBI can objectively measure the anxiety relief, that not are correlate haematic levels of DBI and score scale, that the best benzodiazepines are diazepam (0.3) and flunitrazepam (0.015) and that the prometazine might give anxiety relief for 5-HT antagonist action. Even if there are limits to study (scanty cases, are missing the range and the brain values of DBI and blood test of DBI is slow method) may be useful the use of score scale and haematic levels of DBI in clinical evaluation of preoperative anxiety relief.
对48例外科手术患者使用焦虑评分量表（状态-特质焦虑问卷，Y型，1-2）和DBI（地西泮结合抑制剂）的血液水平，来对术前用药前后的术前焦虑进行临床评估。随机分组后，根据术前用药（地西泮0.3mg/kg；氟硝西泮0.03mg/kg；生理盐水；异丙嗪0.7mg/kg）将6组进行临床和统计学比较；在术前用药前后，使用评分量表、DBI血液水平和血流动力学（收缩压和舒张压以及心率）评估焦虑缓解情况。结果显示，DBI能够客观地测量焦虑缓解情况，DBI血液水平与评分量表不相关，最佳的苯二氮䓬类药物是地西泮（0.3）和氟硝西泮（0.015），并且异丙嗪可能因其5-羟色胺拮抗剂作用而缓解焦虑。即使本研究存在局限性（病例较少，缺少DBI的范围和脑值，且DBI血液检测方法较慢），但在术前焦虑缓解的临床评估中使用评分量表和DBI血液水平可能会有帮助。
