Hovi-Viander M, Kangas L, Kanto J
J Oral Surg. 1980 Mar;38(3):188-90.
The clinical effects of pentobarbital, 100 mg, and diazepam, 10 mg, given orally as preoperative medications before dental surgery were tested in a double-blind study in 50 adult patients. The concnetrations of pentobarbital and diazepam (plus its three active metabolites) in plasma, measured by gas chromatography, were correlated with their clinical effects as assessed both subjectively and objectively (sedation, apprehension, excitement, dizziness, pre- and post-operative emetic effect, increase or decrease in systolic blood pressure, pulse rate, and ease of venipuncture). No significant difference in the effects of these two agents was observed, nor was there any obvious relationship between the concentration in plasma and clinical effect.
在一项针对50名成年患者的双盲研究中，测试了口服100毫克戊巴比妥和10毫克地西泮作为牙科手术前的术前用药的临床效果。通过气相色谱法测定血浆中戊巴比妥和地西泮（及其三种活性代谢物）的浓度，并将其与主观和客观评估的临床效果相关联（镇静、焦虑、兴奋、头晕、术前和术后催吐效果、收缩压、脉搏率的升高或降低以及静脉穿刺的难易程度）。未观察到这两种药物效果的显著差异，血浆浓度与临床效果之间也没有明显关系。
