Kitamura Takashi, Mishina Masayoshi, Sugiyama Hiroyuki
Department of Biology, Graduate School of Science, Kyushu University, 6-10-1 Hakozaki, Fukuoka 812-8581, Japan.
Neurosci Lett. 2006 Jan 30;393(2-3):94-6. doi: 10.1016/j.neulet.2005.08.073. Epub 2005 Dec 13.
Neurogenesis occurs in the adult hippocampus and is promoted by various stimulatory factors, such as enriched environments, running exercises, learning and dietary restriction. We have previously shown that the promotion of adult neurogenesis in the hippocampus by running wheel exercise is mediated by NMDA receptors. In the present study, we report that dietary restriction enhanced the hippocampal neurogenesis in mice lacking NMDA receptor epsilon1 subunit as well as wild-type mice. This result suggests that the molecular mechanism by which dietary restriction promotes adult neurogenesis may be, in contrast to that of running exercise, independent on the NMDA receptor functions.
神经发生在成年海马体中发生，并且受到各种刺激因素的促进，如丰富的环境、跑步运动、学习和饮食限制。我们之前已经表明，通过转轮运动促进成年海马体中的神经发生是由NMDA受体介导的。在本研究中，我们报告饮食限制增强了缺乏NMDA受体ε1亚基的小鼠以及野生型小鼠的海马体神经发生。这一结果表明，与跑步运动相比，饮食限制促进成年神经发生的分子机制可能独立于NMDA受体功能。
