Romain N, Dandrifosse G, Jeusette F, Forget P
Laboratory of Biochemistry and General Physiology, University of Liege, Belgium.
Pediatr Res. 1992 Jul;32(1):58-63. doi: 10.1203/00006450-199207000-00011.
The polyamine concentration in rat milk and food, human milk, and infant formulas was estimated by HPLC. In rat milk, the concentration of putrescine and spermine was low (generally under 2.5 nmol.mL-1 for putrescine and under 1 nmol.mL-1 for spermine). The spermidine concentration was higher and seemed to increase during lactation. The rat food was richer in polyamines than the rat milk (about 150 times for putrescine and spermine, about 30 times for spermidine). We already proved that ingestion of spermine or spermidine can induce precocious maturation of the rat intestine. The present observations suggest that polyamines contained in rat food could play an important role in postnatal maturation of the rat intestine. The polyamine concentration of human milk was measured from 60 different mothers during a period extending from the 1st wk to the 6th mo of lactation. Great variation was observed. During the 1st mo of lactation, the general pattern was as follows: putrescine concentration generally varied little (from 1 to 3 nmol.mL-1), spermine and spermidine concentrations showed a similar pattern (the highest values appeared at the end of the 1st wk of suckling). After the 4th mo of lactation, putrescine concentration increased slightly, whereas spermine and spermidine concentration stayed almost stable. The concentrations of polyamines in 18 powdered milks for babies were estimated. Spermine and spermidine contents were lower than those in human milk. A protective effect of spermine or spermidine against alimentary allergies is suggested.
采用高效液相色谱法（HPLC）测定了大鼠乳汁与食物、人乳及婴儿配方奶粉中的多胺浓度。大鼠乳汁中，腐胺和精胺的浓度较低（腐胺一般低于2.5 nmol/mL，精胺低于1 nmol/mL）。亚精胺浓度较高，且在哺乳期似乎有所增加。大鼠食物中的多胺含量比大鼠乳汁丰富（腐胺和精胺约为150倍，亚精胺约为30倍）。我们已经证明，摄入精胺或亚精胺可诱导大鼠肠道早熟。目前的观察结果表明，大鼠食物中含有的多胺可能在大鼠肠道出生后的成熟过程中发挥重要作用。在哺乳期第1周持续至第6个月的期间，对60位不同母亲的人乳多胺浓度进行了测定。观察到有很大差异。在哺乳期第1个月，一般情况如下：腐胺浓度通常变化不大（1至3 nmol/mL），精胺和亚精胺浓度呈现相似模式（最高值出现在哺乳第1周结束时）。哺乳期第4个月后，腐胺浓度略有增加，而精胺和亚精胺浓度几乎保持稳定。对18种婴儿奶粉中的多胺浓度进行了测定。精胺和亚精胺含量低于人乳。提示精胺或亚精胺对食物过敏有保护作用。
