Muñoz-Esparza Nelly C, Comas-Basté Oriol, Latorre-Moratalla M Luz, Veciana-Nogués M Teresa, Vidal-Carou M Carmen
Departament de Nutrició, Ciències de l'Alimentació i Gastronomia, Facultat de Farmàcia i Ciències de l'Alimentació, Campus de l'Alimentació de Torribera, Universitat de Barcelona, Av. Prat de la Riba 171, 08921 Santa Coloma de Gramenet, Spain.
Institut de Recerca en Nutrició i Seguretat Alimentària (INSA·UB), Universitat de Barcelona, Av. Prat de la Riba 171, 08921 Santa Coloma de Gramenet, Spain.
Foods. 2021 Nov 19;10(11):2866. doi: 10.3390/foods10112866.
Human milk is the gold standard for nutrition during the first months of life, but when breastfeeding is not possible, it may be replaced by infant formulas, either partially or totally. Polyamines, which play an important role in intestinal maturation and the development of the immune system, are found both in human milk and infant formulas, the first exogenous source of these compounds for the newborn. The aim of this study was to evaluate the occurrence and evolution of polyamines in human milk during the first semester of lactation and to compare the polyamine content with that of infant formulas. In total, 30 samples of human milk provided by six mothers during the first five months of lactation as well as 15 different types of infant formulas were analyzed using UHPLC-FL. Polyamines were detected in all human milk samples but with great variation among mothers. Spermidine and spermine levels tended to decrease during the lactation period, while putrescine remained practically unchanged. Considerable differences were observed in the polyamine contents and profiles between human milk and infant formulas, with concentrations being up to 30 times lower in the latter. The predominant polyamines in human milk were spermidine and spermine, and putrescine in infant formulas.
母乳是婴儿出生后最初几个月营养的黄金标准，但在无法进行母乳喂养时，可用婴儿配方奶粉部分或完全替代。多胺在肠道成熟和免疫系统发育中发挥重要作用，在母乳和婴儿配方奶粉中均有发现，婴儿配方奶粉是新生儿获取这些化合物的首个外源来源。本研究的目的是评估哺乳期前半年母乳中多胺的出现情况及变化，并将多胺含量与婴儿配方奶粉进行比较。总共使用超高效液相色谱 - 荧光检测法（UHPLC - FL）分析了六位母亲在哺乳期前五个月提供的30份母乳样本以及15种不同类型的婴儿配方奶粉。在所有母乳样本中均检测到多胺，但母亲之间差异很大。亚精胺和精胺水平在哺乳期趋于下降，而腐胺基本保持不变。母乳和婴儿配方奶粉的多胺含量及分布存在显著差异，后者的浓度低至前者的30倍。母乳中主要的多胺是亚精胺和精胺，而婴儿配方奶粉中是腐胺。
