Braillon P M, Salle B L, Brunet J, Glorieux F H, Delmas P D, Meunier P J
INSERM Unit 234, Edouard Herriot Hospital, Lyon, France.
Pediatr Res. 1992 Jul;32(1):77-80. doi: 10.1203/00006450-199207000-00015.
To evaluate the applicability of dual energy x-ray bone absorptiometry in newborns, precision and accuracy of the method was tested for very small quantities of mineral ranging from less than 0.5 g to about 4 g of hydroxyapatite using a Hologic QDR 1000 instrument. For six femurs excised from preterm stillborns, the mean precision for bone mineral content (BMC) and bone mineral density (BMD) was 1.2 and 0.8%, respectively. Accuracy based on ash weight indicated a mean overestimation of about 7%. In vivo, the precision was assessed by measuring lumbar spine BMC and BMD (L1 to L5) two or three times in 10 newborns (gestational age, 33 to 40 wk). The mean coefficients of variation were 2.40 and 1.55% for BMC and BMD, respectively. Lumbar spine BMC and BMD were also measured once in 30 full-term infants. Values ranged from 1.17 to 3.90 g for BMC and from 0.192 to 0.356 g/cm2 for BMD. The present study shows that dual energy x-ray absorptiometry provides a valuable new tool for the assessment and management of BMC in low birth weight infants and neonates in general.
为评估双能X线骨密度仪在新生儿中的适用性，使用Hologic QDR 1000仪器，针对极少量矿物质（范围从小于0.5克至约4克羟基磷灰石）对该方法的精密度和准确性进行了测试。对于从早产死胎中取出的六根股骨，骨矿物质含量（BMC）和骨矿物质密度（BMD）的平均精密度分别为1.2%和0.8%。基于灰重的准确性表明平均高估约7%。在活体中，通过对10名新生儿（胎龄33至40周）的腰椎BMC和BMD（L1至L5）进行两到三次测量来评估精密度。BMC和BMD的平均变异系数分别为2.40%和1.55%。还对30名足月儿的腰椎BMC和BMD进行了一次测量。BMC值范围为1.17至3.90克，BMD值范围为0.192至0.356克/平方厘米。本研究表明，双能X线吸收法为评估和管理低出生体重婴儿及一般新生儿的BMC提供了一种有价值的新工具。
