Krawczuk-Rybak M, Muszyńska-Rosłan K, Kitszel A, Sawicka-Zukowska M, Wołczyński S
Department of Pediatric Oncology, Medical University of Białystok, Poland.
Rocz Akad Med Bialymst. 2005;50:208-11.
The aim of the study was to estimate the anthropometric parameters and their relationship to serum levels of IGF-I, IGF-II, IGFBP-3, IGFBP-2 and leptin before and during intensive antineoplastic treatment for acute lymphoblastic leukaemia in children.
In 46 children in median age 6.6 years (range from 1.6 to 16) we evaluated at the time of diagnosis, after protocol I and after intensive treatment, height, body mass index (BMI) and IGF-I, IGF-II, IGFBP-3, IGFBP-2 and leptin.
Height SDS lowered in successive points of analysis whereas BMI SDS rose after protocol II. IGF-I SDS was low and similar at each point, IGF-II SDS and IGFBP-3 SDS values augmented progressively and IGFBP-2 SDS was significantly elevated before treatment and lowered (but not normalized) during the therapy. Leptin SDS was elevated, especially after protocol I.
Leukaemia and its treatment affect directly growth factors, its binding proteins and leptin production leading to growth retardation and overweight.
本研究旨在评估儿童急性淋巴细胞白血病强化抗肿瘤治疗前及治疗期间的人体测量参数及其与血清胰岛素样生长因子-I（IGF-I）、胰岛素样生长因子-II（IGF-II）、胰岛素样生长因子结合蛋白-3（IGFBP-3）、胰岛素样生长因子结合蛋白-2（IGFBP-2）和瘦素水平的关系。
对46名中位年龄6.6岁（范围1.6至16岁）的儿童，在诊断时、方案I后及强化治疗后，评估身高、体重指数（BMI）以及IGF-I、IGF-II、IGFBP-3、IGFBP-2和瘦素。
在连续分析点，身高标准差分值（SDS）降低，而方案II后BMI SDS升高。IGF-I SDS在各点均较低且相似，IGF-II SDS和IGFBP-3 SDS值逐渐升高，IGFBP-2 SDS在治疗前显著升高，治疗期间降低（但未恢复正常）。瘦素SDS升高，尤其是在方案I后。
白血病及其治疗直接影响生长因子、其结合蛋白和瘦素的产生，导致生长发育迟缓及超重。
