Chrostek L, Tomaszewski W, Szmitkowski M
Department of Biochemical Diagnostics, Medical University of Białystok, Poland.
Rocz Akad Med Bialymst. 2005;50:220-3.
Alterations in the redox state during chronic ethanol consumption are associated with the oxidation of ethanol via alcohol and aldehyde dehydrogenase. Among various antioxidants present in food, strong antioxidative effects have been attributed to polyphenols of green tea. The aim of the present study was to investigate the effect of green tea consumption during chronic ethanol intake on the activity of aldehyde dehydrogenase in the liver of rats during maturation and aging.
The activity of ALDH was measured in the livers of rats aged 2 (young), 12 (adult) and 24 months (old). The rats were fed with a control liquid Lieber DeCarli diet, control liquid diet containing green tea (3 g/l), ethanol liquid diet (with increasing ethanol dose from 2.3% to 7%) and ethanol liquid diet containing green tea.
Chronic ethanol consumption significantly increased the liver ALDH activity in young and adult rats but decreased this activity in old animals. The drinking of green tea did not alter ALDH activity in ethanol-consuming rats. Drinking green tea alone significantly increased ALDH activity in young and adult rats but did not alter this activity in old rats.
These results demonstrate that green tea administered during chronic ethanol consumption does not prevent the changes in the hepatic ALDH activity in the rats at each age.
长期摄入乙醇期间氧化还原状态的改变与乙醇通过醇脱氢酶和醛脱氢酶的氧化作用有关。在食物中存在的各种抗氧化剂中，绿茶中的多酚具有很强的抗氧化作用。本研究的目的是调查在长期摄入乙醇期间饮用绿茶对大鼠肝脏中醛脱氢酶活性在成熟和衰老过程中的影响。
在2个月（幼年）、12个月（成年）和24个月（老年）的大鼠肝脏中测量醛脱氢酶（ALDH）的活性。给大鼠喂食对照液体利伯·德卡利饮食、含绿茶（3克/升）的对照液体饮食、乙醇液体饮食（乙醇剂量从2.3%增加到7%）和含绿茶的乙醇液体饮食。
长期摄入乙醇显著增加了幼年和成年大鼠肝脏中的ALDH活性，但降低了老年动物的该活性。饮用绿茶并未改变摄入乙醇大鼠的ALDH活性。单独饮用绿茶显著增加了幼年和成年大鼠的ALDH活性，但未改变老年大鼠的该活性。
这些结果表明，在长期摄入乙醇期间给予绿茶并不能防止各年龄段大鼠肝脏中ALDH活性的变化。
