Uścinowicz M, Kaczmarski M
III Department of Paediatrics, Medical University of Białystok, Poland.
Rocz Akad Med Bialymst. 2005;50:257-60.
Cholecystokinin regulates gut motility and visceral sensation. The aim of the study was to determine the diagnostic value of plasma cholecystokinin octapeptide (CCK-8) concentration in children with functional abdominal pain (FAP).
Fifty-two children (33 girls and 19 boys) aged 6-17 years with chronic abdominal pain were included in this study. On the basis of clinical data, results of endoscopy and Criteria for Functional Disorders the patients were divided into three groups: group 1--functional dyspepsia (FD), group 2--irritable bowel syndrome (IBS), group 3--non-specific FAP. The control group consisted of children without abdominal pain in anamnesis. CCK-8 concentrations in plasma were measured with radio immunoassay technique, after plasma extraction. In study protocol we analysed CCK-8 levels in fasting state and 15, 30, 60 minutes after a standard test meal.
In the fasting state plasma levels of CCK-8 were similar in each group and in controls. In the IBS patients CCK-8 levels were not increased after meal. In groups 1, 3 and controls postprandial levels were higher when compared to fasting state (p<0.05). Area under curve of CCK-8 plasma concentration was the lowest in group 2, but not significant compared to controls and other groups. No correlation was found between main symptoms of FD and IBS and CCK-8 concentration in plasma.
We conclude that gut dysmotility and symptoms of functional abdominal pain in children are not concerned with alteration of plasma CCK-8 levels before and after meal.
胆囊收缩素调节肠道蠕动和内脏感觉。本研究旨在确定血浆胆囊收缩素八肽（CCK-8）浓度在儿童功能性腹痛（FAP）中的诊断价值。
本研究纳入了52名6至17岁患有慢性腹痛的儿童（33名女孩和19名男孩）。根据临床资料、内镜检查结果和功能性疾病标准，将患者分为三组：第1组——功能性消化不良（FD），第2组——肠易激综合征（IBS），第3组——非特异性FAP。对照组由既往无腹痛的儿童组成。血浆提取后，采用放射免疫测定技术测量血浆中CCK-8的浓度。在研究方案中，我们分析了空腹状态下以及标准试验餐后15、30、60分钟时的CCK-8水平。
在空腹状态下，每组患者和对照组的血浆CCK-8水平相似。IBS患者餐后CCK-8水平未升高。与空腹状态相比，第1组、第3组和对照组餐后水平更高（p<0.05）。第2组CCK-8血浆浓度的曲线下面积最低，但与对照组和其他组相比无显著差异。未发现FD和IBS的主要症状与血浆CCK-8浓度之间存在相关性。
我们得出结论，儿童肠道动力障碍和功能性腹痛症状与进餐前后血浆CCK-8水平的改变无关。
