Dybek K, Kubis A, Małolepsza-Jarmołowska K
Faculty of Pharmacy, Department of Pharmaceutical Technology, Medical Academy, Wrocław, Poland.
Pharmazie. 1992 Feb;47(2):132-3.
To increase resistance of gelatinous dressings to the etching action of trypsin in vitro, the Kunitz' protease inhibitor has been added. It has been found that the etching rate of the dressings was reduced in proportion to the inhibitor added. Addition of plasticizers in the presence of an inhibitor reduces the etching rate of the dressings and the effect depends on the type and concentration of the plasticizer added. Thermally sterilized dressings have an average of 10% less resistance to the etching action of trypsin. The liberation of the inhibitor from the dressings follows first order kinetics, whereas its liberation rate depends upon the type of the plasticizer used.
为了提高凝胶敷料在体外对胰蛋白酶蚀刻作用的抵抗力，已添加了库尼茨蛋白酶抑制剂。已发现敷料的蚀刻速率与添加的抑制剂成比例降低。在有抑制剂存在的情况下添加增塑剂会降低敷料的蚀刻速率，且效果取决于所添加增塑剂的类型和浓度。热灭菌敷料对胰蛋白酶蚀刻作用的抵抗力平均降低10%。抑制剂从敷料中的释放遵循一级动力学，而其释放速率取决于所用增塑剂的类型。
