Małecka K, Kubis A
Department of Pharmaceutical Technology, Faculty of Pharmacy, Silesian Piasts Memorial Medical Academy, Wrocław, Poland.
Pharmazie. 1996 Apr;51(4):240-1.
Adhesion of xerogel dressings prepared on Eudragit (E), methylcellulose (MC) and glycerol compositions, remaining within the range of 625-650 g, after addition polyvinylpyrolidone (PVP) amounts to 450-1250 g. Dissolution time from xerogel dressings without PVP additive both in water and in an artificial gastric juice amounts to 3 h. Addition of PVP results in reduction of the elution rate. In dependence upon the PVP/E/MC ratio elution time amounts to 3-3.5 h. Pharmaceutical availability of the Kunitz protease inhibitor in particular groups of then dressings depends upon concentration of hydrophilizing agent. The semi-liberation times amounts to 3.65-17.50 h.
在Eudragit（E）、甲基纤维素（MC）和甘油组合物上制备的干凝胶敷料，添加聚乙烯吡咯烷酮（PVP）后其粘附力保持在625 - 650克范围内，PVP的添加量为450 - 1250克。不含PVP添加剂的干凝胶敷料在水和人工胃液中的溶解时间均为3小时。添加PVP会导致洗脱速率降低。根据PVP/E/MC比例不同，洗脱时间为3 - 3.5小时。特定组敷料中Kunitz蛋白酶抑制剂的药物可利用度取决于亲水剂的浓度。半释放时间为3.65 - 17.50小时。
