Malecka K, Kubis A A
Department of Pharmaceutical Technology, Faculty of Pharmacy, Silesian Piasts Memorial Medical Academy, Wroclaw, Poland.
Pharmazie. 1998 Jun;53(6):396-8.
Adhesion of xerogel dressings prepared on Eudragit-E 100, methylcellulose and glycerol compositions in acetone/water mixtures, remains within the range of 317-967 g, after addition of polyvinylpyrrolidone (PVP), it increases to 633-1200 g. Dissolution time of dressings in water amounts to 6 h, in artificial gastric juice to 3 h. Addition of PVP results in decrease of the elution rate, dissolution time amounts to 2.5 h. The Kunitz protease inhibitor semi-liberation times amount to 3.3-7.6 h.
在丙酮/水混合物中由丙烯酸树脂E100、甲基纤维素和甘油组合物制备的干凝胶敷料的粘附力在317 - 967克范围内，添加聚乙烯吡咯烷酮（PVP）后，增加到633 - 1200克。敷料在水中的溶解时间为6小时，在人工胃液中为3小时。添加PVP会导致洗脱速率降低，溶解时间为2.5小时。库尼茨蛋白酶抑制剂的半释放时间为3.3 - 7.6小时。
