Malecka K, Kubis A A
Department of Pharmaceutical Technology, Faculty of Pharmacy, Silesian Piasts Memorial Medical Academy, Wroclaw, Poland.
Pharmazie. 1998 Jun;53(6):396-8.
Adhesion of xerogel dressings prepared on Eudragit-E 100, methylcellulose and glycerol compositions in acetone/water mixtures, remains within the range of 317-967 g, after addition of polyvinylpyrrolidone (PVP), it increases to 633-1200 g. Dissolution time of dressings in water amounts to 6 h, in artificial gastric juice to 3 h. Addition of PVP results in decrease of the elution rate, dissolution time amounts to 2.5 h. The Kunitz protease inhibitor semi-liberation times amount to 3.3-7.6 h.