Mandelbaum David E, Stevens Michael, Rosenberg Eric, Wiznitzer Max, Steinschneider Mitchell, Filipek Pauline, Rapin Isabelle
Department of Clinical Neurosciences, Brown Medical School, Providence, RI, USA.
Dev Med Child Neurol. 2006 Jan;48(1):33-9. doi: 10.1017/S0012162206000089.
The purpose of the study was to determine the prevalence of 'soft' motor deficits in school-aged children with either developmental language disorder (DLD), autism (with high IQ [HiAD] or low IQ [LoAD]), or low IQ without autism (LoIQ), and to evaluate the utility of a refined neurological examination to discriminate between these groups. A total of 242 children (74% male), aged 7 or 9 years, were evaluated as part of a longitudinal, multi-institutional study, with a standardized neurological examination that included Denckla's Physical and Neurological Examination for Soft Signs. Most of the scores separated children into two groups defined by nonverbal IQ, with the DLD and HiAD groups performing better than the LoAD and LoIQ groups. Exceptions included motor impersistence and stereotypies, which were more likely in the autistic groups. The neurologists' summary clinical impressions indicated better sensory/motor skills, oromotor skills, and praxis in the HiAD than in the DLD children. Inability/unwillingness to perform tasks was much more frequent in LoAD than LoIQ children.
本研究的目的是确定患有发育性语言障碍（DLD）、自闭症（高智商[HiAD]或低智商[LoAD]）或无自闭症的低智商儿童（LoIQ）的学龄儿童中“软性”运动缺陷的患病率，并评估一种改良的神经学检查在区分这些组别的效用。作为一项纵向、多机构研究的一部分，对总共242名7岁或9岁的儿童（74%为男性）进行了评估，采用标准化神经学检查，其中包括丹克拉软性体征体格和神经学检查。大多数分数将儿童分为由非言语智商定义的两组，DLD组和HiAD组的表现优于LoAD组和LoIQ组。例外情况包括运动持续性和刻板动作，在自闭症组中更常见。神经科医生的总结临床印象表明，HiAD儿童的感觉/运动技能、口部运动技能和实践能力比DLD儿童更好。LoAD儿童比LoIQ儿童更频繁地出现无法/不愿意执行任务的情况。
