Kim Se-Won, Kim Hyung-Gun, Lee Byung-Eui, Hwang Hyeon-Hwan, Baek Dong-Heon, Ko Seon-Yle
Oscotec Inc. 2-17, Omok-ri, Seonggeo-eup, Cheonan, Choongnam, 330-831, Republic of Korea.
Clin Nutr. 2006 Feb;25(1):166-70. doi: 10.1016/j.clnu.2005.10.014. Epub 2005 Dec 15.
We performed the present study to investigate whether Pleurotus eryngii extracts (PEX) play a role in bone metabolism. PEX treatment showed increase in the alkaline phosphatase activity of the osteoblasts and in the osteocalcin mRNA expression from primary osteoblasts. PEX also increased the expression of the Runx2 gene, and the secretion of osteoprotegerin from the osteoblasts showed marked increases after treatment with PEX. In addition, PEX treatment decreased the number of tartrate-resistant acid phosphatase (TRAP)-positive multinucleated cells and resorption areas. In vivo studies, using rats with ovariectomy-induced osteoporosis revealed that PEX alleviated the decrease in the trabecular bond mineral density.
我们进行了本研究，以调查杏鲍菇提取物（PEX）是否在骨代谢中发挥作用。PEX处理显示成骨细胞的碱性磷酸酶活性增加，以及原代成骨细胞中骨钙素mRNA表达增加。PEX还增加了Runx2基因的表达，并且在用PEX处理后，成骨细胞中骨保护素的分泌显著增加。此外，PEX处理减少了抗酒石酸酸性磷酸酶（TRAP）阳性多核细胞的数量和吸收面积。在体内研究中，使用去卵巢诱导骨质疏松的大鼠表明，PEX减轻了小梁骨矿物质密度的降低。
