Lubitz Carrie C, Gallagher Lisa A, Finley David J, Zhu Baixin, Fahey Thomas J
Department of Surgery, Weill Medical College of Cornell University, New York, NY 10021, USA.
Surgery. 2005 Dec;138(6):1042-8; discussion 1048-9. doi: 10.1016/j.surg.2005.09.009.
While the majority of minimally invasive follicular thyroid carcinoma (MIFTC) behave like follicular adenomas, some recur or metastasize. These studies were conducted to determine if molecular profiling can enhance our understanding of MIFTC and to perhaps offer a better classification schema.
Microarray analysis was performed on 27 follicular neoplasms. Thirteen follicular adenomas (FAs) were compared with 7 widely invasive follicular thyroid carcinomas (WIFTCs) to generate a list of differentially expressed genes. Next, 7 MIFTCs were analyzed along with the other samples in a cluster analysis. The MIFTCs were then compared directly against both the adenoma and WIFTC groups to investigate genetic relatedness.
FAs and WIFTCs have distinct genetic profiles, with 401 differentially expressed genes. The 7 MIFTCs were added to the analysis. Six of 7 of the MIFTCs were grouped with the adenomas, 4 of which created their own subgroup. When analyzed directly, MIFTCs had 223 differently expressed genes, compared with FAs, and 365, compared with WIFTCs.
Molecular profiling illustrates that the majority of MIFTCs comprise a subclass of follicular neoplasms, and, while most MIFTCs are genetically similar to adenomas, our patient data suggest that these tumors may deserve greater suspicion of malignant potential. Gene profiling can provide insight into the molecular pathogenesis of MIFTC.
虽然大多数微小浸润性滤泡状甲状腺癌（MIFTC）的行为类似于滤泡性腺瘤，但有些会复发或转移。进行这些研究是为了确定分子谱分析是否能增进我们对MIFTC的理解，并可能提供更好的分类方案。
对27个滤泡性肿瘤进行微阵列分析。将13个滤泡性腺瘤（FAs）与7个广泛浸润性滤泡状甲状腺癌（WIFTCs）进行比较，以生成差异表达基因列表。接下来，在聚类分析中对7个MIFTC与其他样本一起进行分析。然后将MIFTC直接与腺瘤组和WIFTC组进行比较，以研究遗传相关性。
FAs和WIFTCs具有不同的基因谱，有401个差异表达基因。将7个MIFTC加入分析。7个MIFTC中有6个与腺瘤归为一组，其中4个形成了自己的亚组。直接分析时，与FAs相比，MIFTC有223个差异表达基因，与WIFTCs相比有365个差异表达基因。
分子谱分析表明，大多数MIFTC构成滤泡性肿瘤的一个亚类，虽然大多数MIFTC在基因上与腺瘤相似，但我们的患者数据表明，这些肿瘤可能更值得怀疑具有恶性潜能。基因谱分析可以深入了解MIFTC的分子发病机制。
