Cleary-Goldman Jane, D'Alton Mary E, Berkowitz Richard L
Columbia University Medical Center, New York, NY 10032, USA.
Semin Perinatol. 2005 Oct;29(5):312-20. doi: 10.1053/j.semperi.2005.08.005.
The incidence of twins, triplets, and high-order multiples has increased dramatically in the last two decades secondary to greater reliance on fertility treatments and to delayed childbearing. Offspring of a multiple gestation are at increased risk for both chromosomal and structural abnormalities. Prenatal diagnosis in these patients is challenging. Options for screening tests are limited. Invasive diagnostic procedures are complex. Likewise, physicians and patients may be faced with the dilemma of deciding how to manage discordant results. The following paper will review the unique concerns associated with prenatal diagnosis in a multiple pregnancy and the current methods of prenatal screening in these patients. Invasive prenatal diagnosis will also be explored.
在过去二十年中，由于对辅助生殖技术的更多依赖以及生育年龄的推迟，双胞胎、三胞胎及多胞胎的发生率急剧上升。多胎妊娠的后代出现染色体和结构异常的风险增加。对这些患者进行产前诊断具有挑战性。筛查测试的选择有限。侵入性诊断程序复杂。同样，医生和患者可能会面临如何处理不一致结果的两难境地。以下论文将综述与多胎妊娠产前诊断相关的独特问题以及这些患者目前的产前筛查方法。还将探讨侵入性产前诊断。
