Cleary-Goldman Jane, Berkowitz Richard L
Columbia University Medical Center, New York, NY 10032, USA.
Semin Perinatol. 2005 Dec;29(6):395-400. doi: 10.1053/j.semperi.2006.01.002.
The incidence of twins, triplets, and high-order multiples has increased substantially in the last two decades secondary to fertility treatments and to delayed childbearing. Prenatal diagnosis in these patients is challenging. Options for screening tests are limited. First trimester screening for Down syndrome in patients with multiples appears promising. This paper will review the advantages of first trimester screening in this high-risk patient population.
在过去二十年中，由于生育治疗和生育年龄推迟，双胞胎、三胞胎及多胞胎的发生率大幅上升。对这些患者进行产前诊断具有挑战性。筛查测试的选择有限。孕早期对多胞胎患者进行唐氏综合征筛查似乎很有前景。本文将综述在这一高危患者群体中进行孕早期筛查的优势。
