年龄界限是否仍被用于确定染色体异常侵入性检测的候选对象？
Are age cutoffs still used to identify candidates for invasive testing for chromosomal abnormalities?
作者信息
Wasden Shane W, Adams Brandi N, Chasen Stephen T
机构信息
Department of Obstetrics and Gynecology, Weill Medical College of Cornell University, New York, New York, USA.
出版信息
J Reprod Med. 2011 Mar-Apr;56(3-4):113-6.
OBJECTIVE
Our objective was to determine whether women > or = age 35 are more likely to undergo invasive testing after risk adjustment as compared with younger women at similar adjusted risk.
STUDY DESIGN
Results of first-trimester combined aneuploidy risk assessment of singleton pregnancies from 2007-2008 were reviewed. For each level of adjusted risk, the rate of invasive testing (CVS or amniocentesis) was compared for those < age 35 and those > or = age 35. Spearman correlation, Fisher's exact test, and chi2 for trend were used for statistical comparison.
RESULTS
For all categories except adjusted risk of 1 in < or = 250, women > or = age 35 were significantly more likely to undergo invasive testing as compared with younger women of similar risk. In women > or = age 35 with low adjusted risk, we observed a trend towards lower rates of invasive testing over time.
CONCLUSION
The higher rate of invasive testing in those > or = 35 indicates that women are still being categorized based on age, though our data suggest this may be decreasing.
目的
我们的目的是确定与处于相似调整后风险的年轻女性相比，年龄大于或等于35岁的女性在风险调整后是否更有可能接受侵入性检测。
研究设计
回顾了2007 - 2008年单胎妊娠孕早期联合非整倍体风险评估的结果。对于每个调整后风险水平，比较了年龄小于35岁和年龄大于或等于35岁的女性的侵入性检测（绒毛取样或羊膜穿刺术）率。使用Spearman相关性分析、Fisher精确检验和趋势卡方检验进行统计学比较。
结果
除了调整后风险为1/250或更低的所有类别外，与具有相似风险的年轻女性相比，年龄大于或等于35岁的女性接受侵入性检测的可能性显著更高。在调整后风险较低的年龄大于或等于35岁的女性中，我们观察到随着时间推移侵入性检测率有下降趋势。
结论
年龄大于或等于35岁的女性侵入性检测率较高，这表明女性仍在按年龄分类，尽管我们的数据表明这种情况可能正在减少。
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