Kudo Noriko, Kasai Kiyoto, Itoh Kenji, Koshida Ichiro, Yumoto Masato, Kato Masato, Kamio Satoru, Araki Tsuyoshi, Nakagome Kazuyuki, Fukuda Masato, Yamasue Hidenori, Yamada Haruyasu, Abe Osamu, Kato Nobumasa, Iwanami Akira
Department of Cognitive and Information Sciences, Graduate School of Humanities, Chiba University, Chiba, Japan.
Biol Psychol. 2006 Jan;71(1):54-62. doi: 10.1016/j.biopsycho.2005.01.011.
The auditory mismatch negativity (MMN) or its magnetic counterpart (magnetic mismatch field, MMF) has been widely used to assess the ability of stimulus-driven change detection process in humans. The authors evaluated the similarity of inter-individual variation of the response strength between MMN and MMF recordings. Three types of MMN or MMF were recorded in ten healthy subjects: change in duration of pure-tone stimuli, change in duration of the Japanese vowel /a/, and difference between the Japanese vowels /a/ and /o/. There was no significant correlation between MMN amplitude and MMF strength under any condition and in either hemisphere. These results suggest that widely used indices of MMN in the two technologies, i.e., EEG-amplitude and MEG-ECD may not be proportional in an individual. To further clarify the differential significance of recording MMN/MMF may be important to establish MMN/MMF as clinical indices of individual ability of preattentive stage of auditory processing.
听觉失匹配负波（MMN）或其磁对应物（磁失匹配场，MMF）已被广泛用于评估人类刺激驱动的变化检测过程的能力。作者评估了MMN和MMF记录之间反应强度的个体间变化的相似性。在10名健康受试者中记录了三种类型的MMN或MMF：纯音刺激持续时间的变化、日语元音/a/持续时间的变化以及日语元音/a/和/o/之间的差异。在任何条件下和任何半球中，MMN振幅与MMF强度之间均无显著相关性。这些结果表明，两种技术中广泛使用的MMN指标，即脑电图振幅和脑磁图等效电流偶极子（MEG-ECD）在个体中可能不成比例。为了进一步阐明记录MMN/MMF的差异意义，对于将MMN/MMF确立为听觉处理前注意阶段个体能力的临床指标可能很重要。
