A prospective randomized double blind study of perioperative antibiotic use in the grafting of ulcers of the lower extremity.

We conducted a prospective, randomized, double blind study of the use of a perioperative antibiotic in the skin grafting of arterial and venous ulcers of the lower extremity. Ninety-four patients were randomized and 90 were available for analysis. There was no statistically significant difference in graft "take" or incidence of recipient site infection in the antibiotic versus the no antibiotic group.