Zuber M, Dürig M, Neff U, Laffer U
Helv Chir Acta. 1989 Jun;56(1-2):211-5.
A prospective, randomized, double-blind and controlled clinical trial of systemic antibiotic prophylaxis with Cefazolin and Ornidazol (CO) versus Cefazolin and Placebo (CP) was carried out consecutively in 100 patients undergoing elective, colorectal surgery. The incidence of wound infection in the CP-group was 20% (n = 10) and in the CO-group 8% (n = 4) (p less than 0.10 ns). The reduction of anaerobic bacterias from 20% (n = 10) in the CP-group to 0% (n = 0) (CO) was significant (a1 = 0.0139; a2 = 0.0277 s, Fischer's exact test). The time of hospitalization was reduced from 20.3 days (CP) to 16.7 days (CO) (p less than 0.05 s). The agent for antibiotic prophylaxis in elective colorectal surgery is to cover the spectrum of anaerobic bacterias.
对100例接受择期结直肠手术的患者连续进行了一项前瞻性、随机、双盲对照临床试验，比较头孢唑林与奥硝唑（CO）联合全身抗生素预防与头孢唑林与安慰剂（CP）联合全身抗生素预防的效果。CP组伤口感染发生率为20%（n = 10），CO组为8%（n = 4）（p<0.10，无统计学意义）。厌氧细菌的比例从CP组的20%（n = 10）降至CO组的0%（n = 0），差异有统计学意义（a1 = 0.0139；a2 = 0.0277，Fisher精确检验）。住院时间从20.3天（CP）减少至16.7天（CO）（p<0.05，有统计学意义）。择期结直肠手术中抗生素预防用药应覆盖厌氧菌谱。
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