[慢性丙型肝炎患者在干扰素联合利巴韦林治疗期间的视网膜病变]
[Retinopathy during interferon treatment in combination with ribavirin for chronic hepatitis C].
作者信息
Nakamura Toru, Takahashi Haruo, Koike Noboru, Mitsutaka Minami, Soda Mitsutaka, Kimu Myonsugi
机构信息
Department of Ophthalmology, Showa University Northern Yokohama Hospital. 3 5 1 Chigasakichuo, Tsuzuki-ku, Yokohama 224 8503, Japan.
出版信息
Nippon Ganka Gakkai Zasshi. 2005 Nov;109(11):748-52.
PURPOSE
To observe the retinopathy of the patients who received interferon/ribavirin for treatment of chronic hepatitis C.
METHODS
We observed 6 patients(5 males and 1 female) who received interferon/ribavirin for treatment of chronic hepatitis C. Visual acuity tests and detailed fundus examinations were performed monthly during 6 months of interferon/ribavirin therapy.
RESULTS
All patients developed soft retinal exudate and 5 developed retinal blot hemorrhage. None of the patients exhibited visual impairment or subjective symptoms during the treatment period, and the retinopathy disappeared or decreased in all patients. All of the patients in this study developed interferon retinopathy while undergoing interferon/ribavirin combination therapy.
CONCLUSION
Because the combination of ribavirin with interferon may increase the incidence of interferon retinopathy, and cases of severe retinal complications have also been reported, careful fundus examinations should be performed during combination therapy, just as they are performed during conventional interferon therapy.
目的
观察接受干扰素/利巴韦林治疗慢性丙型肝炎患者的视网膜病变情况。
方法
我们观察了6例接受干扰素/利巴韦林治疗慢性丙型肝炎的患者（5例男性，1例女性）。在干扰素/利巴韦林治疗的6个月期间，每月进行视力测试和详细的眼底检查。
结果
所有患者均出现软性视网膜渗出，5例出现视网膜点状出血。治疗期间所有患者均未出现视力损害或主观症状，且所有患者的视网膜病变均消失或减轻。本研究中所有患者在接受干扰素/利巴韦林联合治疗时均发生了干扰素视网膜病变。
结论
由于利巴韦林与干扰素联合使用可能会增加干扰素视网膜病变的发生率，并且也有严重视网膜并发症的病例报道，因此在联合治疗期间应像常规干扰素治疗时一样进行仔细的眼底检查。
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