丙型肝炎患者聚乙二醇干扰素和利巴韦林相关视网膜病变
[Pegylated interferon and ribavirin associated retinopathy in patients with hepatitis C].
作者信息
Burgueño-Montañés C, Pérez-Álvarez R
机构信息
Servicio de Oftalmología, Hospital Universitario Central de Asturias, Oviedo, España.
出版信息
Arch Soc Esp Oftalmol. 2011 Jun;86(6):193-5. doi: 10.1016/j.oftal.2010.12.015. Epub 2011 Apr 29.
CASE REPORT
We describe two patients with chronic hepatitis C, treated with pegylated interferon and ribavirin, who developed multiple cotton-wool spots in the retina of both eyes. The ocular findings were identified as pegylated interferon associated retinopathy, and in one case spontaneously resolved and in the other after the treatment was withdrawn.
DISCUSSION
Interferon is an immunomodulating cytokine used as a first line treatment of hepatitis C. Numerous adverse effects have been reported, but ocular ones are less known. We believe that periodic ophthalmological examinations during this treatment are required in order to detect these complications, which can be serious.
病例报告
我们描述了两名接受聚乙二醇化干扰素和利巴韦林治疗的慢性丙型肝炎患者，他们双眼视网膜出现了多个棉絮斑。眼部检查结果被确定为聚乙二醇化干扰素相关性视网膜病变，其中一例病变自行消退，另一例在停药后消退。
讨论
干扰素是一种免疫调节细胞因子，用作丙型肝炎的一线治疗药物。已报道了许多不良反应，但眼部不良反应却鲜为人知。我们认为，在这种治疗期间需要定期进行眼科检查，以便发现这些可能很严重的并发症。
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