Aslan Muzaffer, Simsek Göksel, Dayi Ertunç
Faculty of Dentistry, Department of Oral and Maxillofacial Surgery, Ataturk University, Erzurum, Turkey.
J Biomater Appl. 2006 Jan;20(3):209-20. doi: 10.1177/0885328206051047.
Hyaluronic acid (HA) is one of the essential components of extracellular matrix, which plays a predominant role in tissue morphogenesis, cell migration, differentiation, and adhesion. Bone allografts are frequently used to repair and reconstruct bone defects. In this study, two cavities of 3 mm diameter and depth have been created in the right tibia of 30 mature rabbits in accordance with the principles of general surgery. One of the cavities in the tibia is filled with HA and bone graft and the other is filled with only spongiosal bone graft, for the purpose of control. On the 20th, 30th, and 40th days, rabbits have been sacrificed in equal numbers and defective regions have been extracted. The Kruskal-Wallis test was applied to the data obtained in the result of histopathologic survey of specimens. In conclusion, the cavities that have been filled with HA and bone graft have shown higher scores than the control group during every period of the study.
透明质酸（HA）是细胞外基质的重要组成部分之一，在组织形态发生、细胞迁移、分化和黏附中起主要作用。同种异体骨移植常用于修复和重建骨缺损。在本研究中，按照普通外科原则，在30只成年兔的右胫骨上制作了两个直径和深度均为3 mm的腔。胫骨上的一个腔填充HA和骨移植材料，另一个仅填充松质骨移植材料作为对照。在第20、30和40天，等量处死兔子并取出缺损区域。对标本组织病理学检查结果获得的数据应用Kruskal-Wallis检验。总之，在研究的每个阶段，填充HA和骨移植材料的腔的评分均高于对照组。
