基于人群样本的偏头痛与亚甲基四氢叶酸还原酶（MTHFR）C677T基因型
Migraine and MTHFR C677T genotype in a population-based sample.
作者信息
Scher Ann I, Terwindt Gisela M, Verschuren W M Monique, Kruit Mark C, Blom Henk J, Kowa Hisanori, Frants Rune R, van den Maagdenberg Arn M J M, van Buchem Mark, Ferrari Michel D, Launer Lenore J
机构信息
Department of Preventive Medicine and Biometrics, Uniformed Services University, Bethesda, MD 20814-4799, USA.
出版信息
Ann Neurol. 2006 Feb;59(2):372-5. doi: 10.1002/ana.20755.
OBJECTIVE
Migraine with aura is associated with increased risk of stroke. The MTHFR C677T genotype has been associated with increased risk of migraine in selected clinical samples and with elevated homocysteine, a risk factor for stroke. We assessed the association of the MTHFR C677T variant with migraine and the mediating effect of cardiovascular risk factors and metabolic markers of genotype status.
METHODS
We compared adult migraineurs with aura (MA; n = 187), without aura (MO; n = 226), and nonmigraineurs (n = 1,212) from the population-based Genetic Epidemiology of Migraine study.
RESULTS
Compared with the wild-type genotype, the T/T genotype was associated with increased odds of MA (odds ratio [OR], 2.05; 95% confidence interval, 1.2-3.4; p < 0.006), with a trend of increasing numbers of T alleles (OR, 1.40; 95% confidence interval, 1.1-1.8; p < 0.007). ORs were slightly attenuated after adjusting for homocysteine.
INTERPRETATION
Risk of MA is associated with MTHFR C674T homozygosity, independent of other cardiovascular risk factors.
目的
伴先兆偏头痛与中风风险增加相关。MTHFR C677T基因型在特定临床样本中与偏头痛风险增加以及同型半胱氨酸水平升高有关，而同型半胱氨酸是中风的一个风险因素。我们评估了MTHFR C677T变异与偏头痛的关联以及心血管危险因素和基因型状态代谢标志物的中介作用。
方法
我们比较了基于人群的偏头痛遗传流行病学研究中的成年伴先兆偏头痛患者（MA；n = 187）、无先兆偏头痛患者（MO；n = 226）和非偏头痛患者（n = 1212）。
结果
与野生型基因型相比，T/T基因型与MA几率增加相关（优势比[OR]，2.05；95%置信区间，1.2 - 3.4；p < 0.006），且T等位基因数量有增加趋势（OR，1.40；95%置信区间，1.1 - 1.8；p < 0.007）。校正同型半胱氨酸后，优势比略有减弱。
解读
MA风险与MTHFR C674T纯合性相关，独立于其他心血管危险因素。
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