Rubino E, Ferrero M, Rainero I, Binello E, Vaula G, Pinessi L
Neurology II, Headache Centre, Department of Neuroscience, University of Torino, Torino, Italy.
Cephalalgia. 2009 Aug;29(8):818-25. doi: 10.1111/j.1468-2982.2007.01400.x. Epub 2007 Aug 21.
There are conflicting data concerning the association between migraine and C677T polymorphism of the MTHFR gene. The C677T polymorphism reduces enzymatic capability by 50% and causes hyperhomocysteinaemia. We performed a meta-analysis of all published studies investigating the association between the MTHFR gene and migraine. Pooled odds ratios (OR) were estimated using random (RE) and fixed effects (FE) models. Among the overall 2961 migraineurs there was no significant difference compared with controls. Only in migraine with aura was the TT genotype associated with a higher risk of disease compared with the CC genotype [FE OR 1.30, 95% confidence interval (CI) 1.06, 1.58; RE OR 1.66, 95% CI 1.06, 2.59]. In the same subgroup a significant difference was observed in the comparison between TT and CT + CC genotypes (FE OR 1.32, 95% CI 1.10, 1.59; RE OR 1.63, 95% CI 1.10, 2.43). This study provides evidence for an association of the MTHFR gene only in migraine with aura.
关于偏头痛与亚甲基四氢叶酸还原酶（MTHFR）基因C677T多态性之间的关联，存在相互矛盾的数据。C677T多态性使酶活性降低50%，并导致高同型半胱氨酸血症。我们对所有已发表的研究进行了荟萃分析，以调查MTHFR基因与偏头痛之间的关联。采用随机效应（RE）模型和固定效应（FE）模型估计合并比值比（OR）。在总共2961名偏头痛患者中，与对照组相比没有显著差异。仅在有先兆偏头痛中，与CC基因型相比，TT基因型与更高的疾病风险相关[固定效应模型OR 1.30，95%置信区间（CI）1.06，1.58；随机效应模型OR 1.66，95%CI 1.06，2.59]。在同一亚组中，TT基因型与CT+CC基因型的比较中观察到显著差异（固定效应模型OR 1.32，95%CI 1.10，1.59；随机效应模型OR 1.63，95%CI 1.10，2.43）。本研究为MTHFR基因仅与有先兆偏头痛存在关联提供了证据。
