Patel Trupti, Bansal Rimpi, Trivedi Priti, Modi Lopa, Shah M J
Department of Pathology, Room No. 412, The Gujarat Cancer and Research Institute, M.P. Shah Cancer Hospital, New Civil Hospital Campus, Asarwa, Ahmedabad-380016, Gujarat, India.
Indian J Pathol Microbiol. 2005 Oct;48(4):482-4.
Metastasis of mesothelioma of the pleura, to the skin and subcutis is an extremely rare occurrence. A 25 year old woman, who had undergone chemotherapy, partial excision of tumor followed by radiotherapy of sarcomatoid mesothelioma of the pleura, presented three months later with painless widespread subcutaneous nodules. FNAC of these nodules reveled pleomorphic malignant spindle shaped cell with epithelioid morphology. The subcutis is a particularly rare site of metastatic sarcomatoid mesothelioma. It is essential to differentiate neoplasm metastatic to the skin and subcutis from primary and benign lesions of the same region. FNAC is accurate and efficient, in conjugation with clinical history, and it also prevents surgical biopsy in the diagnosis of metastatic subcutaneous lesion. To our knowledge, this is the first case, reported till date, in which the sarcomatoid mesothelioma metastasized to the subcutaneous tissue and was diagnosed by fine needle aspiration cytology (FNAC).
胸膜间皮瘤转移至皮肤和皮下组织极为罕见。一名25岁女性，曾接受化疗、肿瘤部分切除及胸膜肉瘤样间皮瘤放疗，三个月后出现无痛性广泛皮下结节。对这些结节进行细针穿刺抽吸活检（FNAC）显示为具有上皮样形态的多形性恶性梭形细胞。皮下组织是肉瘤样间皮瘤转移的一个特别罕见的部位。将转移至皮肤和皮下组织的肿瘤与同一区域的原发性和良性病变区分开来至关重要。FNAC结合临床病史准确且高效，在转移性皮下病变的诊断中还可避免手术活检。据我们所知，这是迄今为止报道的首例肉瘤样间皮瘤转移至皮下组织并通过细针穿刺抽吸细胞学检查（FNAC）确诊的病例。
