Takeda Eiji, Arai Hidekazu, Yamamoto Hironori, Okumura Hisami, Taketani Yutaka
Department of Clinical Nutrition, Institute of Health Biosciences, and The University of Tokushima Graduate School, Japan.
J Med Invest. 2005 Nov;52 Suppl:259-65. doi: 10.2152/jmi.52.259.
Repeated mental stress may lead to chronic alterations in cortisol and catecholamine concentrations and to insulin resistance. Furthermore, chronically elevated cortisol concentrations may favour the development of abdominal obesity and of the metabolic syndrome. Oxidative stress impairs glucose uptake in muscle and fat and correlates with BMI. Obese subjects with type 2 diabetes, especially soon after the onset of diabetes, usually exhibit postprandial hyperglycemia with delayed hyperinsulinemia. It is recognized that insulin resistance causes postprandial hyperglycemia; however, it is also possible that impairment of early insulin secretion in response to an oral glucose load is the reason why postprandial hyperglycemia occurs. Since even modest increases in postprandial glucose values can be a risk factor for cardiovascular disease. Therefore, the effects of palatinose based functional food which reduces postprandial hyperglycemia and hyperinsulinemia were investigated in rats. This novel food definitely reduced visceral fat accumulation and improved insulin sensitivity. Therefore, it is suggested that functional food which suppresses postprandial glucose level is beneficial for both stress and metabolic controls.
反复的精神压力可能导致皮质醇和儿茶酚胺浓度的慢性改变以及胰岛素抵抗。此外，长期升高的皮质醇浓度可能有利于腹部肥胖和代谢综合征的发展。氧化应激会损害肌肉和脂肪中的葡萄糖摄取，并与体重指数相关。患有2型糖尿病的肥胖受试者，尤其是在糖尿病发病后不久，通常表现为餐后高血糖伴胰岛素血症延迟。人们认识到胰岛素抵抗会导致餐后高血糖；然而，口服葡萄糖负荷后早期胰岛素分泌受损也可能是餐后高血糖发生的原因。因为即使餐后血糖值的适度升高也可能是心血管疾病的危险因素。因此，研究了基于帕拉金糖的功能性食品降低餐后高血糖和高胰岛素血症的作用。这种新型食品确实减少了内脏脂肪堆积并改善了胰岛素敏感性。因此，建议抑制餐后血糖水平的功能性食品对压力和代谢控制均有益。
