Paljärvi Tapio, Mäkelä Pia, Poikolainen Kari
Alcohol and Drug Research Group, National Research and Development Centre for Welfare and Health, Helsinki, Finland.
Addiction. 2005 Dec;100(12):1851-9. doi: 10.1111/j.1360-0443.2005.01258.x.
To find out how the frequency of drinking one to two drinks, three to four drinks and five or more drinks of alcohol per drinking occasion predicts injury mortality in 16 years of follow-up among the Finnish 15-69-year-old male population.
Three alcohol surveys conducted in 1969, 1976 and 1984 were pooled and linked with mortality information from the national cause of death register.
Cox proportional hazard models were used for analysing the survival time data.
Drinking at the level of one to two drinks, regardless of frequency, did not elevate the risk of fatal injury, nor did drinking at the level of three to four drinks. Drinking five or more drinks at a time significantly increased the risk of fatal injury in graded relation, compared with those who never drank at that level. The risk was highest for those who drank five or more drinks at a time at least weekly (RR = 5.78, 95% CI = 2.80-11.94), when adjusted for possible confounders.
We found that besides the total volume of consumption, a drinking pattern that involves drinking occasions when consumption exceeds four drinks of alcohol at a time leads to a significant increase in the risk of fatal injury among Finnish men. The risk is highest among those who have the highest annual number of heavy drinking occasions. The finding does not support the hypothesis that alcohol tolerance would lower the risk of fatal injuries among frequent heavy drinkers.
了解芬兰15至69岁男性人群在16年随访期间,每次饮酒场合饮用1至2杯、3至4杯以及5杯或更多杯酒精饮料的频率如何预测伤害死亡率。
将1969年、1976年和1984年进行的三项酒精调查汇总,并与国家死亡原因登记处的死亡率信息相联系。
使用Cox比例风险模型分析生存时间数据。
无论频率如何,饮用1至2杯酒精饮料并未增加致命伤害风险,饮用3至4杯酒精饮料也未增加该风险。与从未在该水平饮酒的人相比,每次饮用5杯或更多杯酒精饮料会显著增加致命伤害风险,且呈分级关系。在调整可能的混杂因素后,对于那些每周至少一次每次饮用5杯或更多杯酒精饮料的人,风险最高(风险比=5.78,95%置信区间=2.80-11.94)。
我们发现,除了饮酒总量外,一种涉及每次饮酒量超过4杯酒精饮料的饮酒模式会导致芬兰男性致命伤害风险显著增加。在每年重度饮酒次数最多的人群中,风险最高。这一发现不支持酒精耐受性会降低频繁重度饮酒者致命伤害风险的假设。