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芬兰老年人的饮酒与全因死亡率。

Alcohol consumption and all-cause mortality among elderly in Finland.

机构信息

National Institute for Health and Welfare, Helsinki, Finland.

出版信息

Drug Alcohol Depend. 2010 Jan 15;106(2-3):212-8. doi: 10.1016/j.drugalcdep.2009.08.017. Epub 2009 Sep 25.

Abstract

AIMS

To estimate the gender-specific prevalences of alcohol consumption levels and to investigate the association between heavy drinking and all-cause mortality among elderly males.

DESIGN

A cohort derived from a nationally representative sample of Finns aged >65 years was followed for six years. Number of subjects was 1569 (72.7% of the original sample, 65.3% females, weighted n=1357).

MEASUREMENTS

Alcohol consumption was retrospectively measured by beverage-specific quantity and frequency over a 12-month period. Mortality data were obtained from the official Cause-of-Death Register. Cox proportional hazards models were used to analyse the relative risks (RRs) of death.

FINDINGS

The prevalence of heavy drinking (>8 standard drinks per week) was 20.3% in males and 1.2% in females. Over one-tenth (11.4%) of males reported drinking > or =15 standard drinks per week. Relative death risks suggested a J-curved relationship between alcohol consumption levels and mortality. However, significant curvilinear relationship was not found, when using alcohol consumption as continuous variable. The multivariate adjusted RR of death among moderate drinkers (1-7 drinks per week) vs. abstinent subjects was 0.41 (95% CI=.23-.72). Males drinking > or =15 standard drinks per week had a two-fold multivariate adjusted risk of death (RR=2.11, 95% CI=1.19-3.75) compared with abstinent males. The level of alcohol consumption by females was too low for analysis.

CONCLUSIONS

Heavy drinking is common among Finnish elderly males but not among females. The present study shows an increased all-cause mortality risk for males drinking, on average, more than two standard drinks per day.

摘要

目的

估计酒精消费水平的性别特定患病率,并研究老年男性重度饮酒与全因死亡率之间的关系。

设计

本队列研究来源于一项对芬兰 65 岁以上人群的全国代表性样本,随访 6 年。研究对象为 1569 人(原始样本的 72.7%,女性占 65.3%,加权 n=1357)。

测量方法

通过特定饮料的数量和频率在 12 个月期间回顾性地测量酒精摄入量。死亡率数据来自官方死因登记处。使用 Cox 比例风险模型分析死亡的相对风险(RR)。

结果

男性重度饮酒(>8 标准饮料/周)的患病率为 20.3%,女性为 1.2%。超过十分之一(11.4%)的男性报告每周饮用>或=15 标准饮料。相对死亡风险表明酒精摄入量与死亡率之间存在 J 形关系。然而,当使用酒精摄入量作为连续变量时,并未发现显著的曲线关系。与禁欲组相比,适度饮酒者(每周 1-7 杯)的死亡多变量调整 RR 为 0.41(95%CI=.23-.72)。与禁欲男性相比,每周饮用>或=15 标准饮料的男性的死亡多变量调整 RR 为 2.11(95%CI=1.19-3.75)。由于女性的饮酒水平太低,无法进行分析。

结论

在芬兰老年男性中,重度饮酒很常见,但在女性中并非如此。本研究表明,男性平均每天饮用超过两杯标准饮料会增加全因死亡率的风险。

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