Richardson William D, Kessaris Nicoletta, Pringle Nigel
Wolfson Institute for Biomedical Research and Department of Biology, University College London, Gower Street, London WC1E 6BT, UK.
Nat Rev Neurosci. 2006 Jan;7(1):11-8. doi: 10.1038/nrn1826.
Oligodendrocyte precursors first arise in a restricted ventral part of the embryonic spinal cord and migrate laterally and dorsally from there. Later, secondary sources develop in the dorsal cord. Normally, the ventrally-derived precursors compete with and suppress their dorsal counterparts. There are also ventral and dorsal sources in the forebrain, but here the more dorsal precursors prevail and the ventral-most lineage is eliminated during postnatal life. How do the different populations compete and what is the outcome of the competition? Do different embryonic origins signify different functional subgroups of oligodendrocyte?
少突胶质细胞前体细胞最初出现在胚胎脊髓有限的腹侧部分,并从那里向外侧和背侧迁移。后来,背侧脊髓中出现了次级来源。正常情况下,腹侧来源的前体细胞与背侧来源的前体细胞竞争并抑制它们。前脑也有腹侧和背侧来源,但在这里,背侧来源的前体细胞占优势,最腹侧的谱系在出生后被消除。不同群体如何竞争,竞争的结果是什么?不同的胚胎起源是否意味着少突胶质细胞的不同功能亚群?