一种涉及一锅串联氢甲酰化-氢化序列的3-羟基-2-甲基丙酰胺的高选择性合成方法。
A highly selective synthesis of 3-hydroxy-2-methylpropionamide involving a one-pot tandem hydroformylation-hydrogenation sequence.
作者信息
García Luis, Claver Carmen, Diéguez Montserrat, Masdeu-Bultó Anna M
机构信息
Departament de Química Física i Inorgànica, Universitat Rovira i Virgili, Campus Sescelades, Tarragona, Spain.
出版信息
Chem Commun (Camb). 2006 Jan 14(2):191-3. doi: 10.1039/b510813f. Epub 2005 Nov 16.
DOI:10.1039/b510813f
PMID:16372102
Abstract
3-Hydroxy-2-methylpropionamide, an important intermediate in the synthesis of methyl methacrylate, has been obtained with excellent conversion and high selectivity from acrylamide by a tandem hydroformylation-hydrogenation sequence catalysed by Rh/PPh3 and Raney Ni, respectively.
摘要
3-羟基-2-甲基丙酰胺是甲基丙烯酸甲酯合成中的一种重要中间体，通过分别由铑/三苯基膦和雷尼镍催化的串联氢甲酰化-氢化反应序列，从丙烯酰胺出发，以优异的转化率和高选择性获得了该产物。
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