咪达唑仑抑制大鼠海马体中由新事物恐惧症诱导的Fos蛋白表达。
Midazolam inhibits neophobia-induced Fos expression in the rat hippocampus.
作者信息
Wisłowska-Stanek A, Zienowicz M, Lehner M, Taracha E, Bidziński A, Maciejak P, Skórzewska A, Szyndler J, Płaźnik A
机构信息
Department of Experimental and Clinical Pharmacology, Medical University, Warsaw, Poland.
出版信息
J Neural Transm (Vienna). 2006 Jan;113(1):43-8. doi: 10.1007/s00702-005-0398-x.
The effect of midazolam on expression of c-Fos protein was examined in the rat hippocampus, following the open field test of neophobia. It was found that pretreatment of rats with midazolam, at the dose of 0.5 mg/kg, enhanced rat exploratory behavior, and inhibited neophobia related stimulation of c-Fos in the CA-1 and CA-3 areas of the hippocampus. The presented results provide new immunocytochemical data on the involvement of hippocampus in emotional processes related to neophobia, and indicate a possible site of action of benzodiazepines.
在对大鼠进行新物恐惧旷场试验后，研究了咪达唑仑对大鼠海马体中c-Fos蛋白表达的影响。结果发现，以0.5mg/kg的剂量对大鼠进行咪达唑仑预处理，可增强大鼠的探索行为，并抑制新物恐惧相关的海马体CA-1和CA-3区c-Fos的刺激。研究结果提供了关于海马体参与新物恐惧相关情绪过程的新免疫细胞化学数据，并指出了苯二氮䓬类药物可能的作用位点。
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