Wang B E, Cheng J S
Department of Neurobiology, Shanghai Medical University, China.
Zhongguo Yao Li Xue Bao. 1994 Jan;15(1):73-5.
C-fos proteins were visualized immunohistochemically in the brain of rats after seizures induced by injecting penicillin into hippocampus and by penicillin+electroacupuncture treatment. Three hours following seizures there was an evident expression of c-fos proteins in the hippocampus (CA1 area), dentate gyrus, piriform cortex, dorsal part of entorhinal cortex, and amygdaloid nucleus, and there was a dramatic increase of c-fos proteins in CA3 area and the areas mentioned above except the CA1 area where c-fos proteins apparently decreased after electroacupuncture treatment. The results showed that seizures can induce c-fos proteins in some nuclei related with seizure and that electroacupuncture can also regulates the c-fos expression after seizure.
通过向海马体注射青霉素以及采用青霉素+电针治疗诱导大鼠癫痫发作后，用免疫组织化学方法观察大鼠脑内的C-fos蛋白。癫痫发作3小时后，海马体（CA1区）、齿状回、梨状皮质、内嗅皮质背侧部分和杏仁核中有明显的C-fos蛋白表达，并且CA3区以及上述除CA1区外的区域中C-fos蛋白显著增加，而电针治疗后CA1区的C-fos蛋白明显减少。结果表明，癫痫发作可在一些与癫痫相关的核团中诱导C-fos蛋白表达，并且电针也可调节癫痫发作后的C-fos表达。
