Plaznik A, Jessa M, Bidzinski A, Nazar M
Department of Pharmacology and Physiology of the Nervous System, Institute of Psychiatry and Neurology, Warsaw, Poland.
Eur J Pharmacol. 1994 May 23;257(3):293-6. doi: 10.1016/0014-2999(94)90141-4.
The effect of intra-hippocampal (dentate gyrus) microinjections of the benzodiazepine, midazolam (10 micrograms per site, bilaterally), was examined in the Vogel conflict test in serotonin depleted rats (pretreated with p-chlorophenylalanine). p-Chlorophenylalanine and midazolam, when given separately, significantly disinhibited rat conflict behavior. Midazolam retained its anticonflict potency in the p-chlorophenylalanine pretreated animals. These and other data indicate: (i) the specific involvement of limbic serotonin in emotional control, (ii) a dissociation of the effects of serotonin depletion and intra-hippocampal benzodiazepine on conflict behavior, and (iii) the important role of the hippocampus in processing emotional input.
在对用对氯苯丙氨酸预处理过的血清素耗竭大鼠进行的Vogel冲突试验中，研究了海马体内（齿状回）微量注射苯二氮䓬类药物咪达唑仑（每侧位点10微克）的效果。对氯苯丙氨酸和咪达唑仑单独给药时，均能显著解除对大鼠冲突行为的抑制。在经对氯苯丙氨酸预处理的动物中，咪达唑仑仍保持其抗冲突效力。这些数据及其他数据表明：（i）边缘系统血清素在情绪控制中具有特定作用；（ii）血清素耗竭和海马体内注射苯二氮䓬类药物对冲突行为的影响存在分离；（iii）海马体在处理情绪输入方面具有重要作用。
