Seif F J, Sadowski P, Heni F, Fischer R, Bloom S R, Polak J M
Dtsch Med Wochenschr. 1975 Feb 28;100(9):399-405. doi: 10.1055/s-0028-1106226.
A 40-year-old man with the Verner-Morrison syndrome (refractory watery diarrhoea and hypokalaemia in islet-cell tumour of the pancreas) had an islet-cell carcinoma of the non-B-cell type with metastases to liver and mesenteric lymph nodes. High concentrations of a vasoactive intestinal polypeptide (VIP) were demonstrated in tumour tissue and plasma by radioimmunological tests. After surgical removal of the tumour the plasma VIP concentration fell to normal. Immunohistochemical tests of the tumour for gastrointestinal hormones demonstrated marked fluorescence only for vaso-active intestinal polypeptide. It is assumed that this polypeptide is largely responsible for the clinical signs. In the described case the severe watery diarrhoea ceased after glucocorticoid administration.
一名患有韦尔纳 - 莫里森综合征（胰腺胰岛细胞瘤导致难治性水样腹泻和低钾血症）的40岁男性，患有非B细胞型胰岛细胞癌，并伴有肝转移和肠系膜淋巴结转移。通过放射免疫试验在肿瘤组织和血浆中检测到高浓度的血管活性肠多肽（VIP）。手术切除肿瘤后，血浆VIP浓度降至正常。对肿瘤进行的胃肠道激素免疫组织化学检测显示，仅血管活性肠多肽有明显荧光。推测该多肽在很大程度上导致了临床症状。在所描述的病例中，糖皮质激素给药后严重水样腹泻停止。
