Grossniklaus H E
Department of Ophthalmology, Emory University School of Medicine, Atlanta, Ga.
Arch Ophthalmol. 1992 Jul;110(7):969-76. doi: 10.1001/archopht.1992.01080190075033.
Fine-needle aspiration biopsy (FNAB) specimens obtained from nine consecutive iris lesions were examined. The lesions included primary malignant melanoma (four cases), metastatic melanoma, metastatic adenocarcinoma, leukemic infiltrate, lymphocytic infiltrate, and epithelial ingrowth. Subsequent histopathologic correlation was performed in all cases. Patient treatment influenced by the results of the FNABs included enucleation (three cases), clinical observation (two cases), external beam irradiation (two cases), resection, and radioactive plaque application. No complications occurred from the FNABs. Fine-needle aspiration biopsy of the iris can be performed with local anesthesia at the slit lamp as an outpatient procedure. In general, FNAB is a safe, effective method of obtaining diagnostic material from primary neoplastic, secondary neoplastic, and degenerative processes involving the iris. Limitations of the procedure include discrepancies in interpretation of the cytologic study and inadequate specimen.
对连续9例虹膜病变获取的细针穿刺活检（FNAB）标本进行了检查。病变包括原发性恶性黑色素瘤（4例）、转移性黑色素瘤、转移性腺癌、白血病浸润、淋巴细胞浸润和上皮内生。所有病例均进行了后续组织病理学对照。受FNAB结果影响的患者治疗包括眼球摘除术（3例）、临床观察（2例）、外照射（2例）、切除术和放射性敷贴治疗。FNAB未出现并发症。虹膜细针穿刺活检可在裂隙灯下局部麻醉作为门诊手术进行。一般来说，FNAB是从涉及虹膜的原发性肿瘤、继发性肿瘤和退行性病变过程中获取诊断材料的一种安全、有效的方法。该操作的局限性包括细胞学研究解读的差异和标本不足。
