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牙齿转位作为一种起源于遗传的疾病。

Dental transposition as a disorder of genetic origin.

作者信息

Ely Nicola J, Sherriff Martyn, Cobourne Martyn T

机构信息

Department of Orthodontics, at Guy's King's College and St Thomas' Hospital, London, UK.

出版信息

Eur J Orthod. 2006 Apr;28(2):145-51. doi: 10.1093/ejo/cji092. Epub 2005 Dec 22.

DOI:10.1093/ejo/cji092
PMID:16373452
Abstract

A sample of 85 dental transpositions in 75 subjects (27 male, 48 female; mean age at diagnosis 12.25 years) involving both maxillary and mandibular arches was analysed using dental panoramic radiographs and clinical records. Transposition affected the maxillary dentition (76 per cent) more frequently than the mandibular dentition (24 per cent). Unilateral transposition accounted for 88 per cent of cases, with the maxilla being involved more commonly than the mandible. Overall, the most common transposition involved the maxillary canine and first premolar (58 per cent). Considering the jaws in isolation, the canine and first premolar were the most commonly affected teeth in the maxilla (83 per cent) whilst in the mandible, the canine and lateral incisor teeth were most commonly transposed (73 per cent). No significant difference in symmetrical distribution of the unilateral transposition sample occurred. There was evidence of associated hypodontia in 41 per cent of the sample; however, if third molars were excluded, this figure decreased to 25 per cent. Peg-shaped maxillary lateral incisors were judged to be present in 27 per cent of subjects, whilst 41 per cent had retained primary teeth; all of these, except one, were primary canines. Overall, the majority of the sample (76 per cent) demonstrated at least one of the dental anomalies under investigation. Multivariate analysis showed associations between unilateral transposition, gender, and the presence of peg-shaped maxillary lateral incisors; whilst bilateral transposition was more closely associated with gender and the presence of retained primary teeth. There was a poor association between both unilateral and bilateral transposition and hypodontia. Together, these results suggest a mutifactorial aetiology to this disorder, with both genetic and environmental factors playing an important role.

摘要

对75名受试者(27名男性,48名女性;诊断时平均年龄12.25岁)的85例牙换位情况进行了分析,这些牙换位涉及上颌和下颌牙弓,分析时使用了牙科全景X线片和临床记录。牙换位影响上颌牙列(76%)的频率高于下颌牙列(24%)。单侧牙换位占病例的88%,上颌比下颌更常受累。总体而言,最常见的牙换位涉及上颌尖牙和第一前磨牙(58%)。单独考虑上下颌时,尖牙和第一前磨牙是上颌最常受累的牙齿(83%),而在下颌,尖牙和侧切牙最常发生换位(73%)。单侧牙换位样本的对称分布没有显著差异。41%的样本有相关牙缺失的证据;然而,如果排除第三磨牙,这一数字降至25%。27%的受试者被判定有上颌侧切牙呈钉状,而41%的受试者有乳牙滞留;除一颗外,所有这些都是乳尖牙。总体而言,大多数样本(76%)表现出至少一种所研究的牙齿异常。多变量分析显示单侧牙换位、性别和上颌侧切牙呈钉状之间存在关联;而双侧牙换位与性别和乳牙滞留的存在更密切相关。单侧和双侧牙换位与牙缺失之间的关联较弱。这些结果共同表明该疾病的病因是多因素的,遗传和环境因素都起着重要作用。

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