进食和饥饿大鼠灌注肝脏中R-和S-1,3-丁二醇的代谢
Metabolism of R- and S-1,3-butanediol in perfused livers from meal-fed and starved rats.
作者信息
Desrochers S, David F, Garneau M, Jetté M, Brunengraber H
机构信息
Department of Biochemistry, University of Montreal, Quebec, Canada.
出版信息
Biochem J. 1992 Jul 15;285 ( Pt 2)(Pt 2):647-53. doi: 10.1042/bj2850647.
Abstract
The metabolism of millimolar concentrations of R- or S-1,3-butanediol has been studied in perfused livers from fed and starved rats. Protocols were designed to measure in the same experiment (i) uptake of the diol, (ii) the contribution of the diol to ketogenesis, (iii) the contribution of the diol to total fatty acid plus sterol synthesis, and (iv) conversion of S-1,3-butanediol into S-3-hydroxybutyrate. Our data show that R- and S-1,3-butanediol are taken up by the liver at the same rate. Most of the metabolism of R-1,3-butanediol is accounted for by conversion to the physiological ketone bodies R-3-hydroxybutyrate and acetoacetate. Only 29-38% of S-1,3-butanediol uptake is accounted for by conversion into physiological ketone bodies. The balance of S-1,3-butanediol metabolism is conversion to S-3-hydroxybutyrate, lipids and CO2.
摘要
已在喂食和饥饿大鼠的灌注肝脏中研究了毫摩尔浓度的R-或S-1,3-丁二醇的代谢情况。实验方案设计为在同一实验中测量：(i)二醇的摄取；(ii)二醇对生酮作用的贡献；(iii)二醇对总脂肪酸加固醇合成的贡献；以及(iv)S-1,3-丁二醇转化为S-3-羟基丁酸酯的情况。我们的数据表明，肝脏对R-和S-1,3-丁二醇的摄取速率相同。R-1,3-丁二醇的大部分代谢是通过转化为生理性酮体R-3-羟基丁酸酯和乙酰乙酸来实现的。S-1,3-丁二醇摄取量中只有29-38%是通过转化为生理性酮体来实现的。S-1,3-丁二醇代谢的其余部分是转化为S-3-羟基丁酸酯、脂质和二氧化碳。
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本文引用的文献
1
The enzymic oxidation of alpha- and 2-beta-hydroxybutyrate.α-和2-β-羟基丁酸的酶促氧化
Biochim Biophys Acta. 1953 Sep-Oct;12(1-2):188-202. doi: 10.1016/0006-3002(53)90138-3.
2
Metabolism of plasma mevalonate in rats and humans.大鼠和人类血浆甲羟戊酸的代谢
J Lipid Res. 1982 May;23(4):577-83.
3
On the lack of formation of L-(+)-3-hydroxybutyrate by liver.关于肝脏中L-(+)-3-羟基丁酸酯的生成缺乏情况。
Arch Biochem Biophys. 1982 Mar;214(1):268-72. doi: 10.1016/0003-9861(82)90030-3.
4
Lipogenesis from ketone bodies in the isolated perfused rat liver. Evidence for the cytosolic activation of acetoacetate.离体灌注大鼠肝脏中酮体的脂肪生成。乙酰乙酸胞质活化的证据。
J Biol Chem. 1982 Apr 10;257(7):3434-40.
5
The fate of the ethanol analogue 1,3-butanediol in the dog. An in vivo-in vitro comparison.乙醇类似物1,3 - 丁二醇在犬体内的代谢情况。体内 - 体外比较研究
Biochem Pharmacol. 1981 Jul 15;30(14):1987-97. doi: 10.1016/0006-2952(81)90210-0.
6
Determination of 14C-labelled ketone bodies by liquid-scintillation counting.通过液体闪烁计数法测定14C标记的酮体。
Biochem J. 1967 Jan;102(1):230-5. doi: 10.1042/bj1020230.
7
Utilization by the rat of 1,3-butanediol as a synthetic source of dietary energy.
J Nutr. 1967 Jan;91(1):79-88. doi: 10.1093/jn/91.1.79.
8
3- -Hydroxysterol synthesis by the liver.肝脏合成3-β-羟基类固醇。
Arch Biochem Biophys. 1972 Jun;150(2):392-6. doi: 10.1016/0003-9861(72)90054-9.
9
Utilization of 1,3-butanediol and nonspecific nitrogen in human adults.1,3 - 丁二醇和非特异性氮在成年人中的利用情况。
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