喂食和饥饿大鼠的灌注肝脏对3-羟基丁酸形成及极低密度脂蛋白三酰甘油分泌的调节
Regulation of 3-hydroxybutyrate formation and secretion of very-low-density-lipoprotein triacylglycerol by perfused livers from fed and starved rats.
作者信息
Laker M E, Mayes P A
出版信息
Biochem J. 1982 Aug 15;206(2):427-30. doi: 10.1042/bj2060427.
Abstract
Acetoacetate was the sole ketone body formed when livers from starved rats were perfused with minimal concentrations of non-esterified fatty acid. Absence of 3-hydroxybutyrate was related to a low substrate potential, which caused a more oxidized redox state and a decreased [ATP]/[ADP] ratio. Only under conditions of comparable non-esterified fatty acid uptake was lipoprotein triacylglycerol production inversely related to ketogenesis.
摘要
当用最低浓度的非酯化脂肪酸灌注饥饿大鼠的肝脏时，乙酰乙酸是唯一生成的酮体。缺乏3-羟基丁酸与底物电位低有关，这导致氧化还原状态更高且[ATP]/[ADP]比值降低。只有在非酯化脂肪酸摄取相当的条件下，脂蛋白三酰甘油的产生才与酮生成呈负相关。
相似文献
1
Regulation of 3-hydroxybutyrate formation and secretion of very-low-density-lipoprotein triacylglycerol by perfused livers from fed and starved rats.喂食和饥饿大鼠的灌注肝脏对3-羟基丁酸形成及极低密度脂蛋白三酰甘油分泌的调节
Biochem J. 1982 Aug 15;206(2):427-30. doi: 10.1042/bj2060427.
2
Rates of ketone-body formation in the perfused rat liver.灌注大鼠肝脏中酮体生成的速率。
Biochem J. 1969 May;112(5):595-600. doi: 10.1042/bj1120595.
3
Differential effects of alanine on ketogenesis and triacylglycerol formation by isolated perfused livers from euthyroid and hyperthyroid rats.丙氨酸对正常甲状腺和甲状腺功能亢进大鼠分离灌注肝脏生酮作用及三酰甘油形成的不同影响。
Metabolism. 1985 Dec;34(12):1139-45. doi: 10.1016/0026-0495(85)90160-x.
4
INFLUENCE OF ETHANOL ON THE LIVER METABOLISM OF FED AND STARVED RATS.乙醇对喂食及饥饿大鼠肝脏代谢的影响
Biochem J. 1965 Jan;94(1):259-65. doi: 10.1042/bj0940259.
5
Investigations into the direct effects of insulin on hepatic ketogenesis, lipoprotein secretion and pyruvate dehydrogenase activity.胰岛素对肝脏生酮作用、脂蛋白分泌及丙酮酸脱氢酶活性的直接影响的研究。
Biochim Biophys Acta. 1984 Sep 12;795(2):427-30. doi: 10.1016/0005-2760(84)90094-8.
6
Reciprocal effects of dietary sesamin on ketogenesis and triacylglycerol secretion by the rat liver.膳食芝麻素对大鼠肝脏生酮作用和三酰甘油分泌的相互影响。
J Nutr Sci Vitaminol (Tokyo). 1998 Oct;44(5):715-22. doi: 10.3177/jnsv.44.715.
7
A comparison of the utilization of medium and long-chain fatty acids for oxidation and ketogenesis in the suckling rat: in vivo and in vitro studies.哺乳大鼠中长链脂肪酸用于氧化和生酮作用的利用率比较：体内和体外研究
Arch Biochem Biophys. 1981 Oct 15;211(2):537-46. doi: 10.1016/0003-9861(81)90488-4.
8
Effects of ethynyloestradiol on the metabolism of [1-14C]oleate by perfused livers and hepatocytes from female rats.乙炔雌二醇对雌性大鼠灌注肝脏和肝细胞中[1-14C]油酸代谢的影响。
Biochem J. 1979 May 15;180(2):265-71. doi: 10.1042/bj1800265.
9
Increased secretion of triglyceride and cholesterol following inhibition of long-chain fatty acid oxidation in rat liver.大鼠肝脏中长链脂肪酸氧化受抑制后甘油三酯和胆固醇分泌增加。
Ann Nutr Metab. 1996;40(3):157-64. doi: 10.1159/000177909.
10
Comparison of metabolism of free fatty acid by isolated perfused livers from male and female rats.雄性和雌性大鼠离体灌注肝脏对游离脂肪酸代谢的比较。
J Lipid Res. 1976 Nov;17(6):605-15.
引用本文的文献
1
Exercise and dietary-mediated reductions in postprandial lipemia.运动和饮食介导的餐后血脂降低。
J Nutr Metab. 2014;2014:902065. doi: 10.1155/2014/902065. Epub 2014 Jun 29.
2
Peroxisomal beta-oxidation from endogenous substrates. Demonstration through H2O2 production in the unanaesthetized mouse.内源性底物的过氧化物酶体β-氧化。通过未麻醉小鼠体内过氧化氢的产生来证明。
Biochem J. 1984 Mar 15;218(3):697-702. doi: 10.1042/bj2180697.
3
Effect of ethanol on lipid metabolism in cultured hepatocytes.乙醇对培养肝细胞脂质代谢的影响。
Biochem J. 1985 Jun 15;228(3):673-81. doi: 10.1042/bj2280673.
本文引用的文献
1
Effect of hyperthyroidism and hypothyroidism on lipid and carbohydrate metabolism of the perfused rat liver.甲状腺功能亢进和减退对灌注大鼠肝脏脂质及碳水化合物代谢的影响。
Biochem J. 1981 Apr 15;196(1):247-55. doi: 10.1042/bj1960247.
2
3
Regulation of ketogenesis in the liver.
Biochem Soc Trans. 1981 Aug;9(4):339-41. doi: 10.1042/bst0090339.
4
Role of free oxaloacetate in ketogenesis. Derivation from the direct measurement of mitochondrial [3-hydroxybutyrate]/[acetoacetate] ratio in hepatocytes.游离草酰乙酸在生酮作用中的作用。通过直接测量肝细胞中线粒体[3-羟基丁酸酯]/[乙酰乙酸]的比率得出。
Eur J Biochem. 1982 Jan;121(3):493-9. doi: 10.1111/j.1432-1033.1982.tb05814.x.
5
Regulation of fat metabolism of the liver.肝脏脂肪代谢的调节
Nature. 1967 Aug 12;215(5102):716-8. doi: 10.1038/215716a0.
6
The relationship between the rates of conversion of palmitate into citrate or acetoacetate and the acetyl-coenzyme A content of rat-liver mitochondria.棕榈酸转化为柠檬酸或乙酰乙酸的速率与大鼠肝脏线粒体中乙酰辅酶A含量之间的关系。
Biochem J. 1965 Dec;97(3):38C-40C. doi: 10.1042/bj0970038c.
7
8
Metabolism of free fatty acids in isolated liver cells. Factors affecting the partition between esterification and oxidation.分离肝细胞中游离脂肪酸的代谢。影响酯化与氧化分配的因素。
J Biol Chem. 1972 Mar 25;247(6):1788-800.
9
On the maximal possible rate of ketogenesis.
Diabetes. 1972 Jan;21(1):50-3. doi: 10.2337/diab.21.1.50.
Zotero 插件