喂食和饥饿大鼠的灌注肝脏对3-羟基丁酸形成及极低密度脂蛋白三酰甘油分泌的调节
Regulation of 3-hydroxybutyrate formation and secretion of very-low-density-lipoprotein triacylglycerol by perfused livers from fed and starved rats.
作者信息
Laker M E, Mayes P A
出版信息
Biochem J. 1982 Aug 15;206(2):427-30. doi: 10.1042/bj2060427.
Abstract
Acetoacetate was the sole ketone body formed when livers from starved rats were perfused with minimal concentrations of non-esterified fatty acid. Absence of 3-hydroxybutyrate was related to a low substrate potential, which caused a more oxidized redox state and a decreased [ATP]/[ADP] ratio. Only under conditions of comparable non-esterified fatty acid uptake was lipoprotein triacylglycerol production inversely related to ketogenesis.
摘要
当用最低浓度的非酯化脂肪酸灌注饥饿大鼠的肝脏时，乙酰乙酸是唯一生成的酮体。缺乏3-羟基丁酸与底物电位低有关，这导致氧化还原状态更高且[ATP]/[ADP]比值降低。只有在非酯化脂肪酸摄取相当的条件下，脂蛋白三酰甘油的产生才与酮生成呈负相关。
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