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在Fontan姑息治疗中,发病率受分期影响吗?一项单中心回顾研究。

Is morbidity influenced by staging in the fontan palliation? A single center review.

作者信息

Francois K, Tamim M, Bove T, De Groote K, De Wolf D, Matthys D, Suys B, Verhaaren H, Van Nooten G

机构信息

Department of Congenital Cardiac Surgery, University Hospital Gent, Belgium.

出版信息

Pediatr Cardiol. 2005 Jul-Aug;26(4):350-5. doi: 10.1007/s00246-005-8646-2.

DOI:10.1007/s00246-005-8646-2
PMID:16374683
Abstract

In a retrospective study of 32 consecutive patients undergoing a total cavopulmonary connection (TCPC), we tried to determine if the trend for decreasing age at Fontan completion and reducing the intervals between the staged procedures during the past decade was associated with a change in morbidity and outcome. In 8 patients the Fontan circulation was completed in one stage and in 24 patients an intermediate step by hemi-Fontan or bidirectional cavopulmonary anastomosis was performed before Fontan completion. Mean age at TCPC and mean interval since the previous palliation have decreased significantly during the past decade. Although major complications were significantly reduced over time the occurrence and duration of postoperative pleural effusions were not. Decreasing age as well as intervals in staged Fontan palliation have beneficial influence on major complications and outcome, without significantly affecting the duration of pleural effusions at Fontan completion.

摘要

在一项对32例连续接受全腔静脉肺动脉连接术(TCPC)患者的回顾性研究中,我们试图确定在过去十年中,Fontan手术完成时年龄降低的趋势以及分期手术间隔时间缩短是否与发病率和结局的变化相关。8例患者Fontan循环一期完成,24例患者在Fontan手术完成前通过半Fontan或双向腔肺吻合术进行了中间步骤。在过去十年中,TCPC时的平均年龄以及自上次姑息治疗以来的平均间隔时间均显著降低。尽管随着时间推移主要并发症显著减少,但术后胸腔积液的发生率和持续时间并未降低。Fontan分期姑息治疗中年龄降低以及间隔时间缩短对主要并发症和结局有有益影响,而对Fontan手术完成时胸腔积液的持续时间无显著影响。

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本文引用的文献

1
Effect of fenestration on the sub-diaphragmatic venous hemodynamics in the total-cavopulmonary connection.开窗术对全腔静脉肺动脉连接术患者膈下静脉血流动力学的影响。
Eur J Cardiothorac Surg. 2001 Jun;19(6):785-92. doi: 10.1016/s1010-7940(01)00705-9.
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Clinical results of the staged Fontan procedure in high-risk patients.高危患者分期Fontan手术的临床结果。
Ann Thorac Surg. 1998 Jun;65(6):1721-5. doi: 10.1016/s0003-4975(98)00264-1.
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Current status of staged reconstruction for hypoplastic left heart syndrome.
Pediatr Cardiol. 1998 Jul-Aug;19(4):308-15. doi: 10.1007/s002469900314.
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Management of the univentricular connection: are we improving?单心室连接的管理:我们有进步吗?
Eur J Cardiothorac Surg. 1997 Jul;12(1):107-15. doi: 10.1016/s1010-7940(97)00112-7.
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Pulmonary artery growth after bidirectional cavopulmonary shunt: is there a cause for concern?双向腔肺分流术后肺动脉生长:是否值得担忧?
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Staged operation to Fontan increases the incidence of sinoatrial node dysfunction.分期进行Fontan手术会增加窦房结功能障碍的发生率。
J Thorac Cardiovasc Surg. 1996 Apr;111(4):833-9; discussion 839-40. doi: 10.1016/s0022-5223(96)70344-6.
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Univentricular repair. Early and midterm results.单心室修复术。早期和中期结果。
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Ann Thorac Surg. 1993 Mar;55(3):646-51. doi: 10.1016/0003-4975(93)90268-m.
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Fontan's procedure in two stages.两阶段的Fontan手术。
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10
Influence of competitive pulmonary blood flow on the bidirectional superior cavopulmonary shunt. A multi-institutional study.竞争性肺血流对双向腔肺分流术的影响。一项多机构研究。
Circulation. 1995 Nov 1;92(9 Suppl):II279-86. doi: 10.1161/01.cir.92.9.279.