[生存素与p63在喉鳞状细胞癌中的表达及生物学意义]

[Expression and biological significance of survivin and p63 in laryngeal squamous cell carcinoma].

作者信息

Wen Xiaoxia, Gao Ying, Ji Wenyue

机构信息

Department of Otolaryngology, the Fourth Affiliated Hospital of China Medical University, Shenyang, 110032, China.

出版信息

Lin Chuang Er Bi Yan Hou Ke Za Zhi. 2005 Sep;19(18):833-5.

PMID:16375115

Abstract

OBJECTIVE

To investigate the expression of Survivin and p63 and their biological significance in laryngeal squamous cell carcinomas (LSCC).

METHOD

The expression of Survivin and p63 in 47 cases of tumor tissues, adjacent and normal tissues were detected using in situ hybridization.

RESULT

Percentage of Survivin expression was 59.6% (28/47), 25.5% (12/47) in tumor tissues and adjacent tissues respectively. In contrast, normal laryngeal tissues did not express Survivin. Over expression of Survivin was strongly associated with tumor grade, TNM stage and cervical nodal metastasis. Percentage of p63 expression was 91.5% (43/47), 93.6% (44/47), 57.1% (8/14) in tumor tissues, adjacent and normal tissues respectively. The expression of p63 was not related to any clinicopathological features.

CONCLUSION

Survivin may play an important role in the pathway of carcinogenesis and progression of LSCC and it may be identified as a new therapeutic target. The up-regulation of the expression of Survivin predicts more invasion and poor prognosis. p63 has less effect on biological behaviors of LSCC.

摘要

目的

探讨生存素（Survivin）和p63在喉鳞状细胞癌（LSCC）中的表达及其生物学意义。

方法

采用原位杂交法检测47例喉鳞状细胞癌患者肿瘤组织、癌旁组织及正常组织中Survivin和p63的表达。

结果

Survivin在肿瘤组织中的表达率为59.6%（28/47），在癌旁组织中的表达率为25.5%（12/47），而在正常喉组织中无表达。Survivin的过表达与肿瘤分级、TNM分期及颈部淋巴结转移密切相关。p63在肿瘤组织中的表达率为91.5%（43/47），在癌旁组织中的表达率为93.6%（44/47），在正常组织中的表达率为57.1%（8/14）。p63的表达与各临床病理特征均无关。