[生存素基因和PTEN基因在喉鳞状细胞癌中的表达及临床意义]

[Expression and clinical significance of survivin gene and PTEN gene in laryngeal squamous cell carcinomas].

作者信息

Zhu Li, Wang Shuyi

机构信息

Department of Pathology, Affiliated Eye Ear Nose Throat Hospital, Fudan University, Shanghai, 200031, China.

出版信息

Lin Chuang Er Bi Yan Hou Ke Za Zhi. 2006 Dec;20(24):1113-5.

PMID:17357516

Abstract

OBJECTIVE

To investigate the expression and clinical significance of anti-apoptosis gene Survivin and tumor suppressor gene PTEN in laryngeal squamous cell carcinomas (LSCC) METHOD: The expression of Survivin and PTEN protein were detected by immunohistochemistry Envision method in 71 specimens of LSCC, and 10 specimens of vocal cord polyp as control.

RESULT

No Survivin was detected in polyp of vocal cord. However, it was detected in 53 of 71 (74. 6%) specimens from the patients with LSCC. The Survivin expression was unrelated to the age and sex of patients or the size of tumors ( P >0.05) ,but related to the tumor site, clinical stage, histological grade, lymphatic metastasis and tumor prognosis ( P <0. 05). PTEN had the expression in all specimens of vocal cord polyp. However, it was detected in 33 of 71 (46. 5%) specimens of laryngeal carcinoma. The PTEN expression was unrelated to the clinical data including age, gender, tumor size and site ( P >0. 05), but related to the clinical stage, pathological grade, lymph node metastasis and prognosis ( P <0. 05). There was a negative correlation between Survivin expression and PTEN expression ( P <0. 05).

CONCLUSION

The abnormal expression of Survivin and PTEN gene may be related to carcinogenesis, tumor progress and prognosis. The Survivin and PTEN gene may act as markers predicting biological behavior of LSCC. The coexpression of Survivin and PTEN gene have the synergism in carcinogenesis and tumor progress of LSCC.

摘要

目的

探讨抗凋亡基因Survivin和抑癌基因PTEN在喉鳞状细胞癌（LSCC）中的表达及临床意义。方法：采用免疫组织化学Envision法检测71例LSCC标本及10例声带息肉标本中Survivin和PTEN蛋白的表达。

结果

声带息肉中未检测到Survivin。然而，在71例LSCC患者的53例标本（74.6%）中检测到Survivin。Survivin的表达与患者的年龄、性别或肿瘤大小无关（P>0.05），但与肿瘤部位、临床分期、组织学分级、淋巴转移及肿瘤预后有关（P<0.05）。PTEN在所有声带息肉标本中均有表达。然而，在71例喉癌标本中的33例（46.5%）中检测到PTEN。PTEN的表达与年龄、性别、肿瘤大小及部位等临床资料无关（P>0.05），但与临床分期、病理分级、淋巴结转移及预后有关（P<0.05）。Survivin表达与PTEN表达呈负相关（P<0.05）。