[p63基因在喉鳞状细胞癌中表达的临床意义]
[The clinical significance of the expression of p63 gene in laryngeal squamous cell carcinoma].
作者信息
Jia Haiying, Wang Jiqun, Shan Yanchun, Hou Jinghui
机构信息
Departament of Otorhinolaryngology, the First Affiliated Hospital of Jinan University, Guangzhou, China.
出版信息
Lin Chuang Er Bi Yan Hou Ke Za Zhi. 2006 Feb;20(3):119-21.
OBJECTIVE
To study the expression and clinical significance of p63 gene in laryngeal squamous cell carcinoma(LSCC).
METHOD
The immunohistochemical technique was used to detected the expression of p63 in 63 cases of LSCC, 45 cases of para-cancer tissues, 24 cases of lymph node metastasis, 40 cases of non lymph node metastasis and 25 normal tissues.
RESULT
The positive overexpression rate of the p63 gene in LSCC (95.24%) and in matched metastatic lymph node (83.3%) was significantly higher than para cancer tissues, non metastasis lymph node and normal tissues (P<0.01). p63 gene expression was not correlation with the clinical stages,clinical typing and pathological classification of the LSCC(P >0.05).
CONCLUSION
p63 gene had important clinic significance to the diagnosis and differential diagnosis of the LSCC. It perhaps participate in regulation of tumorigenesis in LSCC, and it may play negative feedback action in the development of LSCC.
目的
研究p63基因在喉鳞状细胞癌（LSCC）中的表达及临床意义。
方法
采用免疫组织化学技术检测63例喉鳞状细胞癌、45例癌旁组织、24例有淋巴结转移、40例无淋巴结转移及25例正常组织中p63的表达。
结果
p63基因在喉鳞状细胞癌（95.24%）及配对转移淋巴结（83.3%）中的阳性过表达率显著高于癌旁组织、无转移淋巴结及正常组织（P<0.01）。p63基因表达与喉鳞状细胞癌的临床分期、临床分型及病理分级无关（P>0.05）。
结论
p63基因对喉鳞状细胞癌的诊断及鉴别诊断具有重要临床意义。它可能参与喉鳞状细胞癌肿瘤发生的调控，且可能在喉鳞状细胞癌的发展中起负反馈作用。
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